| Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight. | |
| | |
MedLine Citation:
|
PMID: 19683226 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Several human studies have shown that low-level exposure to environmental contaminants, such as polychlorinated biphenyls (PCBs) and organochlorine pesticides, negatively influences birth outcomes. However, the effects of low-level exposure to polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like PCBs (DL-PCBs) on birth outcomes have not been clarified in human studies. A prospective cohort study was established to investigate the possible adverse effects of PCDDs/PCDFs and DL-PCBs on fetal growth and neurodevelopment. We recruited 514 pregnant women between July 2002 and October 2005 in Sapporo, Japan. We measured 29 congener levels of PCDDs/PCDFs and DL-PCBs in maternal blood. Using multiple liner regression analysis of the association between birth weight and the levels of PCDDs/PCDFs and DL-PCBs with full adjustments for potential confounders, a significant adverse effect was observed regarding total PCDDs toxic equivalents (TEQ) levels (adjusted beta=-231.5g, 95% CI: -417.4 to -45.6) and total PCDFs TEQ levels (adjusted beta=-258.8g, 95% CI: -445.7 to -71.8). Among male infants, significant adverse associations with birth weight were found for total PCDDs TEQ level, total PCDDs/PCDFs TEQ level, and total TEQ level. However, among female infants, these significant adverse associations were not found. With regard to individual congeners of PCDDs/PCDFs and DL-PCBs, we found significantly negative association with the levels of 2,3,4,7,8-PeCDF (adjusted beta=-24.5g, 95% CI: -387.4 to -61.5). Our findings suggest that prenatal low-level exposure to PCDDs and PCDFs, especially 2,3,4,7,8-PeCDF, may accumulate in the placenta and retard important placental functions, which result in lower birth weight. |
| | |
Authors:
|
Kanae Konishi; Seiko Sasaki; Shizue Kato; Susumu Ban; Noriaki Washino; Jumboku Kajiwara; Takashi Todaka; Hironori Hirakawa; Tsuguhide Hori; Daisuke Yasutake; Reiko Kishi |
Related Documents
:
|
18285376 - Predicting significant hyperbilirubinaemia using birth weight. 14722146 - Indirect vs direct hospital quality indicators for very low-birth-weight infants. 10212086 - Relation between size of delivery unit and neonatal death in low risk deliveries: popul... 18257656 - Mortality and morbidity of neonates born at <26 weeks of gestation (1998-2003). a popul... 19307746 - Treatment of posthemorrhagic hydrocephalus in premature infants with subcutaneous reser... 11389286 - Prenatal and postnatal flavor learning by human infants. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-14 |
Journal Detail:
|
Title: Environmental research Volume: 109 ISSN: 1096-0953 ISO Abbreviation: Environ. Res. Publication Date: 2009 Oct |
Date Detail:
|
Created Date: 2009-09-14 Completed Date: 2009-10-01 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0147621 Medline TA: Environ Res Country: United States |
Other Details:
|
Languages: eng Pagination: 906-13 Citation Subset: IM |
Affiliation:
|
Department of Public Health Sciences, Hokkaido University Graduate School of Medicine, North 15-West7, Kita-ku, Sapporo, Hokkaido 060-8638, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Benzofurans / poisoning* Birth Weight / drug effects* Cohort Studies Female Humans Infant, Newborn Japan Linear Models Male Maternal Exposure / adverse effects* Polychlorinated Biphenyls / poisoning* Pregnancy Prospective Studies Tetrachlorodibenzodioxin / analogs & derivatives*, poisoning Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Benzofurans; 0/Polychlorinated Biphenyls; 0/chlorinated dibenzofurans; 0/polychlorodibenzo-4-dioxin; 1746-01-6/Tetrachlorodibenzodioxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Functional neuroanatomy of the encoding and retrieval processes of verbal episodic memory in MCI.
Next Document: PPAR-gamma expression in peritoneal endometriotic lesions correlates with pain experienced by patien...