Document Detail

Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight.
MedLine Citation:
PMID:  19683226     Owner:  NLM     Status:  MEDLINE    
Several human studies have shown that low-level exposure to environmental contaminants, such as polychlorinated biphenyls (PCBs) and organochlorine pesticides, negatively influences birth outcomes. However, the effects of low-level exposure to polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like PCBs (DL-PCBs) on birth outcomes have not been clarified in human studies. A prospective cohort study was established to investigate the possible adverse effects of PCDDs/PCDFs and DL-PCBs on fetal growth and neurodevelopment. We recruited 514 pregnant women between July 2002 and October 2005 in Sapporo, Japan. We measured 29 congener levels of PCDDs/PCDFs and DL-PCBs in maternal blood. Using multiple liner regression analysis of the association between birth weight and the levels of PCDDs/PCDFs and DL-PCBs with full adjustments for potential confounders, a significant adverse effect was observed regarding total PCDDs toxic equivalents (TEQ) levels (adjusted beta=-231.5g, 95% CI: -417.4 to -45.6) and total PCDFs TEQ levels (adjusted beta=-258.8g, 95% CI: -445.7 to -71.8). Among male infants, significant adverse associations with birth weight were found for total PCDDs TEQ level, total PCDDs/PCDFs TEQ level, and total TEQ level. However, among female infants, these significant adverse associations were not found. With regard to individual congeners of PCDDs/PCDFs and DL-PCBs, we found significantly negative association with the levels of 2,3,4,7,8-PeCDF (adjusted beta=-24.5g, 95% CI: -387.4 to -61.5). Our findings suggest that prenatal low-level exposure to PCDDs and PCDFs, especially 2,3,4,7,8-PeCDF, may accumulate in the placenta and retard important placental functions, which result in lower birth weight.
Kanae Konishi; Seiko Sasaki; Shizue Kato; Susumu Ban; Noriaki Washino; Jumboku Kajiwara; Takashi Todaka; Hironori Hirakawa; Tsuguhide Hori; Daisuke Yasutake; Reiko Kishi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-14
Journal Detail:
Title:  Environmental research     Volume:  109     ISSN:  1096-0953     ISO Abbreviation:  Environ. Res.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-14     Completed Date:  2009-10-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0147621     Medline TA:  Environ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  906-13     Citation Subset:  IM    
Department of Public Health Sciences, Hokkaido University Graduate School of Medicine, North 15-West7, Kita-ku, Sapporo, Hokkaido 060-8638, Japan.
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MeSH Terms
Benzofurans / poisoning*
Birth Weight / drug effects*
Cohort Studies
Infant, Newborn
Linear Models
Maternal Exposure / adverse effects*
Polychlorinated Biphenyls / poisoning*
Prospective Studies
Tetrachlorodibenzodioxin / analogs & derivatives*,  poisoning
Young Adult
Reg. No./Substance:
0/Benzofurans; 0/Polychlorinated Biphenyls; 0/chlorinated dibenzofurans; 0/polychlorodibenzo-4-dioxin; 1746-01-6/Tetrachlorodibenzodioxin

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