Document Detail


Prenatal exposure to bisphenol A and phthalates and infant neurobehavior.
MedLine Citation:
PMID:  21854843     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine the association of prenatal exposure to bisphenol A and select common phthalates with infant neurobehavior measured at 5 weeks.
METHODS: We compared the concentration of maternal urinary metabolites of bisphenol A and phthalates at two distinct time points in pregnancy (16w, 26w) with scores on the NICU Network Neurobehavioral Scale (NNNS) at 5 weeks of age in a cohort of 350 mother/infant pairs.
RESULTS: Prenatal exposure to BPA was not significantly associated with neurobehavioral outcomes at 5 weeks. Significant associations between prenatal exposure to measured phthalates and infant neurobehavioral outcomes differed by type of phthalate and were only seen with exposure measured at 26 weeks. Higher total di-butyl phthalate (DBP) metabolites at 26w were associated with improved behavioral organization evidenced by decreased arousal (p=.04), increased self-regulation (p=.052), and decreased handling (p=.02). In males, higher total di-2-ethylhexyl phthalate (DEHP) metabolites at 26w were associated with more nonoptimal reflexes (p=.02).
CONCLUSION: The association between prenatal phthalate exposure and infant neurobehavior differed by type of phthalate and was evident only with exposure measured at 26w. Prenatal exposure to DBP was associated with improved behavioral organization in 5-week-old infants. Prenatal exposure to DEHP was associated with nonoptimal reflexes in male infants. There was no evidence of an association between prenatal BPA exposure and infant neurobehavior.
Authors:
Kimberly Yolton; Yingying Xu; Donna Strauss; Mekibib Altaye; Antonia M Calafat; Jane Khoury
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-08-10
Journal Detail:
Title:  Neurotoxicology and teratology     Volume:  33     ISSN:  1872-9738     ISO Abbreviation:  Neurotoxicol Teratol     Publication Date:    2011 Sep-Oct
Date Detail:
Created Date:  2011-09-29     Completed Date:  2012-01-31     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  8709538     Medline TA:  Neurotoxicol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  558-66     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult
Benzhydryl Compounds
Dibutyl Phthalate / toxicity,  urine
Diethylhexyl Phthalate / toxicity,  urine
Environmental Pollutants / pharmacokinetics,  toxicity*,  urine
Female
Humans
Infant
Male
Neuropsychological Tests / statistics & numerical data
Neurotoxicity Syndromes / diagnosis*
Phenols / toxicity*,  urine
Phthalic Acids / pharmacokinetics,  toxicity*,  urine
Pregnancy
Prenatal Exposure Delayed Effects / psychology*,  urine
Time Factors
Grant Support
ID/Acronym/Agency:
P01 ES011261/ES/NIEHS NIH HHS; P01 ES011261-01/ES/NIEHS NIH HHS; P01 ES11261/ES/NIEHS NIH HHS; R01 ES015517/ES/NIEHS NIH HHS; R01 ES015517/ES/NIEHS NIH HHS; R01 ES015517-01A1/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Benzhydryl Compounds; 0/Environmental Pollutants; 0/Phenols; 0/Phthalic Acids; 2286E5R2KE/Dibutyl Phthalate; 6O7F7IX66E/phthalic acid; C42K0PH13C/Diethylhexyl Phthalate; MLT3645I99/bisphenol A
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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