Document Detail


Prenatal exclusion of metachromatic leukodystrophy by estimation of arylsulphatase A activity in chorion and cultured amniotic fluid cells.
MedLine Citation:
PMID:  6137815     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chorion biopsy specimens were used for prenatal assay of arylsulphatase A activity in a pregnant woman whose two children had died from metachromatic leukodystrophy (MLD). As in two subsequent pregnancies chorion arylsulphatase A was in the control range, it was concluded that both fetuses were healthy. Absence of MLD in the fetus from the first pregnancy was confirmed after assay of arylsulphatase A activity in fetal organs. The second pregnancy resulted in delivery of a healthy child.
Authors:
I V Tsvetkova; T V Zolotukhina; V A Bakharev; E L Rosenfeld; I S Rosovsky
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  3     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  233-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amniocentesis
Amniotic Fluid / cytology,  enzymology*
Biopsy
Cells, Cultured
Cerebroside-Sulfatase / metabolism*
Chorion / enzymology*
Clinical Enzyme Tests*
Female
Humans
Infant, Newborn
Leukocytes / enzymology
Leukodystrophy, Metachromatic / diagnosis*
Pregnancy
Prenatal Diagnosis*
Sulfatases / metabolism*
Chemical
Reg. No./Substance:
EC 3.1.6.-/Sulfatases; EC 3.1.6.8/Cerebroside-Sulfatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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