| Prenatal endocrine activation alters postnatal cellular immunity in infant monkeys. | |
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MedLine Citation:
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PMID: 8954595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cellular immune responses were evaluated in 35 infant rhesus monkeys generated from two types of pregnancy conditions. Pregnant females were administered either saline or adrenocorticotropic hormone (ACTH) for 2 weeks between Days 120 and 133 postconception, approximately 1 month before parturition. After birth, lymphocytes obtained from infants in the ACTH condition failed to respond as readily to allogeneic cells in mixed lymphocyte cultures, proliferated less to Con A, exhibited lower suppressor function following stimulation with Con A, and showed lower cytolytic activity against target cells. For some measures, the prenatal effect was observed more consistently in male infants. Differences were evident with these in vitro immune assays through 6 months of age, indicating that acute disturbance during the prenatal period can have lingering effects on postnatal immunity. |
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Authors:
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C L Coe; G R Lubach; J W Karaszewski; W B Ershler |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain, behavior, and immunity Volume: 10 ISSN: 0889-1591 ISO Abbreviation: Brain Behav. Immun. Publication Date: 1996 Sep |
Date Detail:
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Created Date: 1997-03-19 Completed Date: 1997-03-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8800478 Medline TA: Brain Behav Immun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 221-34 Citation Subset: IM |
Affiliation:
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Department of Psychology, University of Wisconsin, Madison 53706, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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pharmacology* Animals Birth Weight / drug effects Cell Division / physiology Concanavalin A / pharmacology Dehydroepiandrosterone / blood Female Gestational Age Hydrocortisone / blood Immunity, Cellular / physiology* Lymphocyte Culture Test, Mixed Lymphocyte Subsets / immunology, physiology Macaca mulatta Male Mitogens / pharmacology Pregnancy Prenatal Exposure Delayed Effects* Progesterone / blood |
| Grant Support | |
ID/Acronym/Agency:
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MH 41659/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Mitogens; 11028-71-0/Concanavalin A; 50-23-7/Hydrocortisone; 53-43-0/Dehydroepiandrosterone; 57-83-0/Progesterone; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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