| Prenatal effects of natural calcium supplement on Wistar rats during organogenesis period of pregnancy. | |
| | |
MedLine Citation:
|
PMID: 21703836 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The potential of oral exposure to calcium and magnesium citrate, a natural product obtained from dolomite, to initiate teratogenesis was analyzed in Wistar rats. Animals received calcium and magnesium citrate oral doses of 250, 500 and 1000mg/kg during the period of gestation from day 6 to 17 post conception. Maternal, embryo and fetal toxicity was evaluated. Calcium and magnesium citrate exposure did not produce maternal toxicity assessed by clinical observations, body weight gain, food intake, hematology, biochemical parameters and necropsy finding. Signs of embryo-fetal toxicity were not observed. Skeletal and visceral malformations were seen occasionally in all drug-treated and control groups. Skeletal and visceral variations were similar in control and drug-treated groups except for incomplete ossification rib. These finding was spontaneous and unrelated to the drug. In conclusion, in this study we found that the oral exposure to rats of up to 1000mg/kg of calcium and magnesium citrate during organogenesis did not induce significant maternal and embryo-fetal toxicity. The experimentally derived NOAEL for developmental toxicity was 1000mg/kg. |
| | |
Authors:
|
Alicia Lagarto; Addis Bellma; Micaela Couret; Tatiana Gabilondo; Raisel López; Viviana Bueno; Isbel Guerra; Jorge Rodríguez |
Related Documents
:
|
3532796 - A link between relative hypoglycemia-hypoinsulinemia during oral glucose tolerance test... 17502346 - Perinatal circulating visfatin levels in intrauterine growth restriction. 21689486 - Environmental toxicant exposure during pregnancy. 7248226 - An ultrastructural study of utero-placental spiral arteries in hypertensive and normote... 21806836 - Spatiotemporal expression of serpine2 in the human placenta and its role in extravillou... 8136286 - Pure red cell aplasia of pregnancy: a distinct clinical entity. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-22 |
Journal Detail:
|
Title: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie Volume: - ISSN: 1618-1433 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-6-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9208920 Medline TA: Exp Toxicol Pathol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier GmbH. All rights reserved. |
Affiliation:
|
Drug Research and Development Center, CIDEM, 17 No. 6208 e/62 y 64, Playa, Código Postal 11300, Ciudad Habana, Havana City, Cuba. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Relationships between serum total bilirubin levels and metabolic syndrome in Korean adults.
Next Document: In vitro assessment of silver effect on porcine ovarian granulosa cells.