Document Detail

Prenatal, early life, and childhood exposure to genotoxicants in the living environment.
MedLine Citation:
PMID:  21183437     Owner:  NLM     Status:  MEDLINE    
Health disorders and diseases related to environmental exposure in children such as cancer and immunologic disturbances (asthma, allergies) are on the rise. However, complex transplacental and prepubertal genotoxicology is given very limited consideration, even though intrauterine development and early childhood may be critical for elucidating the cancer aetiology. The foetus is transplacentally exposed to contaminants in food and environment such as various chemicals, drugs, radiochemically contaminated water and air. Target organs of xenobiotic action may differ between the mother and the foetus due to specific stage of developmental physiology and enzyme distribution. This in turn may lead to different levels of clastogenic and aneugenic metabolites of the same xenobiotic in the mother and the foetus. Adult's protective behaviour is not sufficient to isolate children from radioisotopes, pesticides, toxic metals and metalloids, environmental tobacco smoke, endocrine disrupting chemicals, and various food contaminants, which are just a part of the stressors present in a polluted environment. In order to improve legislation related to foetus and child exposure to genotoxic and possibly carcinogenic agents, oncologists, paediatricians, environmental health specialists, and genotoxicologists should work together much more closely to make a more effective use of accumulated scientific data, with the final aim to lower cancer incidence and mortality.
Jelena Katić; Aleksandra Fučić; Marija Gamulin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Arhiv za higijenu rada i toksikologiju     Volume:  61     ISSN:  0004-1254     ISO Abbreviation:  Arh Hig Rada Toksikol     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-24     Completed Date:  2011-04-28     Revised Date:  2012-05-03    
Medline Journal Info:
Nlm Unique ID:  0373100     Medline TA:  Arh Hig Rada Toksikol     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  455-64     Citation Subset:  IM    
Institute for Medical Research and Occupational Health, Ksaverska cesta 2, Zagreb, Croatia.
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MeSH Terms
Air Pollutants / adverse effects
Environmental Exposure*
Fetus / drug effects
Food Contamination
Food Contamination, Radioactive
Mutagens / adverse effects*
Prenatal Exposure Delayed Effects*
Water Pollutants, Chemical / adverse effects
Xenobiotics / adverse effects*
Reg. No./Substance:
0/Air Pollutants; 0/Mutagens; 0/Water Pollutants, Chemical; 0/Xenobiotics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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