| Prenatal drug exposure and selective attention in preschoolers. | |
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MedLine Citation:
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PMID: 15939203 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Deficits in sustained attention and impulsivity have previously been demonstrated in preschoolers prenatally exposed to cocaine. We assessed an additional component of attention, selective attention, in a large, poly-substance cocaine-exposed cohort of 4 year olds and their at-risk comparison group. Employing postpartum maternal report and biological assay, we assigned children to overlapping exposed and complementary control groups for maternal use of cocaine, alcohol, marijuana, and cigarettes. Maternal pregnancy use of cocaine and use of cigarettes were both associated with increased commission errors, indicative of inferior selective attention. Severity of maternal use of marijuana during pregnancy was positively correlated with omission errors, suggesting impaired sustained attention. Substance exposure effects were independent of maternal postpartum psychological distress, birth mother cognitive functioning, current caregiver functioning, other substance exposures and child concurrent verbal IQ. |
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Authors:
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Julia S Noland; Lynn T Singer; Elizabeth J Short; Sonia Minnes; Robert E Arendt; H Lester Kirchner; Cynthia Bearer |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2005-03-29 |
Journal Detail:
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Title: Neurotoxicology and teratology Volume: 27 ISSN: 0892-0362 ISO Abbreviation: Neurotoxicol Teratol Publication Date: 2005 May-Jun |
Date Detail:
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Created Date: 2005-06-07 Completed Date: 2005-08-02 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 8709538 Medline TA: Neurotoxicol Teratol Country: United States |
Other Details:
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Languages: eng Pagination: 429-38 Citation Subset: IM |
Affiliation:
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Vanderbilt University, Department of Psychology and Human Development, Peabody College #512, 230 Appleton Place, Nashville, TN 37203-5701, USA. julia.noland@vanderbilt.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Attention / physiology* Attention Deficit Disorder with Hyperactivity / chemically induced, psychology Cannabis / adverse effects Central Nervous System Depressants / adverse effects Child, Preschool Cocaine / adverse effects Data Interpretation, Statistical Ethanol / adverse effects Female Humans Impulsive Behavior / chemically induced, psychology Longitudinal Studies Meconium / chemistry Neuropsychological Tests Parents Pregnancy Prenatal Exposure Delayed Effects* Prospective Studies Psychomotor Performance / drug effects Smoking / adverse effects Substance Abuse Detection Wechsler Scales |
| Grant Support | |
ID/Acronym/Agency:
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F32-05904//PHS HHS; P0 ES11261-01/ES/NIEHS NIH HHS; P30-HD15052/HD/NICHD NIH HHS; R01 DA007957-12S1/DA/NIDA NIH HHS; R01-07957//PHS HHS; R03-AA12618/AA/NIAAA NIH HHS; RR00080/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Depressants; 50-36-2/Cocaine; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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