Document Detail

Prenatal drug exposure and selective attention in preschoolers.
MedLine Citation:
PMID:  15939203     Owner:  NLM     Status:  MEDLINE    
Deficits in sustained attention and impulsivity have previously been demonstrated in preschoolers prenatally exposed to cocaine. We assessed an additional component of attention, selective attention, in a large, poly-substance cocaine-exposed cohort of 4 year olds and their at-risk comparison group. Employing postpartum maternal report and biological assay, we assigned children to overlapping exposed and complementary control groups for maternal use of cocaine, alcohol, marijuana, and cigarettes. Maternal pregnancy use of cocaine and use of cigarettes were both associated with increased commission errors, indicative of inferior selective attention. Severity of maternal use of marijuana during pregnancy was positively correlated with omission errors, suggesting impaired sustained attention. Substance exposure effects were independent of maternal postpartum psychological distress, birth mother cognitive functioning, current caregiver functioning, other substance exposures and child concurrent verbal IQ.
Julia S Noland; Lynn T Singer; Elizabeth J Short; Sonia Minnes; Robert E Arendt; H Lester Kirchner; Cynthia Bearer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2005-03-29
Journal Detail:
Title:  Neurotoxicology and teratology     Volume:  27     ISSN:  0892-0362     ISO Abbreviation:  Neurotoxicol Teratol     Publication Date:    2005 May-Jun
Date Detail:
Created Date:  2005-06-07     Completed Date:  2005-08-02     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  8709538     Medline TA:  Neurotoxicol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  429-38     Citation Subset:  IM    
Vanderbilt University, Department of Psychology and Human Development, Peabody College #512, 230 Appleton Place, Nashville, TN 37203-5701, USA.
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MeSH Terms
Attention / physiology*
Attention Deficit Disorder with Hyperactivity / chemically induced,  psychology
Cannabis / adverse effects
Central Nervous System Depressants / adverse effects
Child, Preschool
Cocaine / adverse effects
Data Interpretation, Statistical
Ethanol / adverse effects
Impulsive Behavior / chemically induced,  psychology
Longitudinal Studies
Meconium / chemistry
Neuropsychological Tests
Prenatal Exposure Delayed Effects*
Prospective Studies
Psychomotor Performance / drug effects
Smoking / adverse effects
Substance Abuse Detection
Wechsler Scales
Grant Support
F32-05904//PHS HHS; P0 ES11261-01/ES/NIEHS NIH HHS; P30-HD15052/HD/NICHD NIH HHS; R01 DA007957-12S1/DA/NIDA NIH HHS; R01-07957//PHS HHS; R03-AA12618/AA/NIAAA NIH HHS; RR00080/RR/NCRR NIH HHS
Reg. No./Substance:
0/Central Nervous System Depressants; 50-36-2/Cocaine; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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