Document Detail

Prenatal differentiation of ventral abdominal wall defects. Are amniotic fluid markers useful adjuncts?
MedLine Citation:
PMID:  1380559     Owner:  NLM     Status:  MEDLINE    
We retrospectively reviewed 29 cases of ventral abdominal wall defects to evaluate the usefulness of amniotic fluid markers in the prenatal assessment of those disorders. Amniotic fluid alpha-fetoprotein (AF-AFP) values were available in 17 cases diagnosed prior to 22 weeks' gestation and acetylcholinesterase (AF-ACE) values, in 21 cases. All 7 fetuses with a gastroschisis had an elevated AF-AFP, while only 2 of the 10 fetuses with an omphalocele had elevated values (P = .002). ACE was present in 80% of the cases of gastroschisis versus 27.3% of the cases of omphalocele (P = .03). With equivocal sonographic findings, a normal AF-AFP and negative AF-ACE may be more compatible with an omphalocele.
J M Tucker; C G Brumfield; R O Davis; C L Winkler; L R Boots; N E Krassikoff; J C Hauth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  37     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-09-24     Completed Date:  1992-09-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  445-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Alabama, Birmingham 35233-7333.
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MeSH Terms
Acetylcholinesterase / chemistry*
Alabama / epidemiology
Amniotic Fluid / chemistry*
Biological Markers / chemistry*
Diagnosis, Differential
Hernia, Umbilical / diagnosis*,  epidemiology
Hernia, Ventral / congenital*,  diagnosis,  epidemiology
Hospitals, University
Infant, Newborn
Pregnancy Outcome
Prenatal Diagnosis / methods,  standards*
Retrospective Studies
Sensitivity and Specificity
Ultrasonography, Prenatal / standards
alpha-Fetoproteins / chemistry*
Reg. No./Substance:
0/Biological Markers; 0/alpha-Fetoproteins; EC

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