| Prenatal diagnosis of trisomy 9 mosaicism: two new cases. | |
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MedLine Citation:
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PMID: 8309895 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We present two prenatal cases of trisomy 9 mosaicism, both of which presented intrauterine growth retardation (IUGR) and other abnormal ultrasound findings. In case A, mosaicism was found in amniotic fluid cell cultures, of which 65 per cent were trisomic cells, on average. In case B, trisomic cells were present in amniotic fluid cell cultures (12 per cent) but none were found in fetal cord blood. After autopsy, cytogenetic findings were confirmed in different tissue cultures. It is concluded that echographic indicators are a very useful tool for a correct prenatal diagnostic interpretation of trisomy 9. Suspected trisomy 9 mosaicism always requires further investigation and fetal cord blood cytogenetic analysis may not be considered as providing an accurate diagnosis of fetal trisomy 9. |
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Authors:
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A Merino; A De Perdigo; F Nombalais; M Yvinec; M G Le Roux; V Bellec |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Prenatal diagnosis Volume: 13 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 1993 Oct |
Date Detail:
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Created Date: 1994-03-17 Completed Date: 1994-03-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1001-7 Citation Subset: IM |
Affiliation:
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Laboratoire de Cytogénétique Anténatale, Centre Hospitalaire et Universitaire de Nantes, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Multiple
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genetics*,
ultrasonography Adult Amniocentesis* Chromosomes, Human, Pair 9* Facial Bones / abnormalities Female Fetal Growth Retardation / genetics, ultrasonography Humans Mosaicism* Pregnancy Pregnancy Trimester, Second Skull / abnormalities Stomach / abnormalities Trisomy* Ultrasonography, Prenatal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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