Document Detail

Prenatal diagnosis of thalassemia: experiences at the Shanghai Children's Hospital.
MedLine Citation:
PMID:  2905348     Owner:  NLM     Status:  MEDLINE    
Using DNA dot-blot hybridization, restriction endonuclease gene mapping with oligonucleotide probes, restriction fragment length polymorphism linkage analysis, and hybridization, prenatal diagnosis was performed for 32 pregnancies at risk for alpha-thalassemia and for 10 pregnancies at risk for beta-thalassemia. The DNA samples were prepared from chorion villi or amniotic fluid cells.
Y T Zeng; S Z Huang; M L Zhang
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hemoglobin     Volume:  12     ISSN:  0363-0269     ISO Abbreviation:  Hemoglobin     Publication Date:  1988  
Date Detail:
Created Date:  1989-02-16     Completed Date:  1989-02-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7705865     Medline TA:  Hemoglobin     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  795-800     Citation Subset:  IM    
Laboratory of Medical Genetics, Shanghai Children's Hospital, P.R. China.
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MeSH Terms
Amnion / cytology
Chorionic Villi Sampling
DNA / genetics,  isolation & purification
Nucleic Acid Hybridization
Oligonucleotides / genetics
Polymorphism, Restriction Fragment Length
Prenatal Diagnosis*
Restriction Mapping
Thalassemia / diagnosis*
Grant Support
Reg. No./Substance:
0/Oligonucleotides; 9007-49-2/DNA

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