| Prenatal diagnosis of some metabolic diseases using early amniotic fluid samples: report of a 15 years, experience. | |
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MedLine Citation:
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PMID: 16821251 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In the present study, we report the results of 132 prenatal diagnoses performed on chorionic villi and cell-free amniotic fluid obtained simultaneously at 12-13 weeks of gestation. In addition, we report the result of 59 prenatal diagnoses performed at 12-13th week using amniotic fluid only. METHODS AND RESULTS: A total of one fetal loss (1/191) was observed when a sample of amniotic fluid was obtained at around 12-13 weeks, whereas three losses (3/82) were observed after midtrimester amniocentesis. We attribute this finding to the fact that only a very small volume of amniotic fluid was sampled using a very small needle. CONCLUSION: From these data it appears that when a couple is facing a high risk of recurrence of some metabolic diseases, the study of chorionic villus and amniotic fluid sampled simultaneously offers a safe and reliable method of early prenatal diagnosis. |
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Authors:
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B Chadefaux-Vekemans; D Rabier; N Cadoudal; A Lescoat; A Chabli; J Aupetit; Y Dumez; J F Oury |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prenatal diagnosis Volume: 26 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-04 Completed Date: 2006-12-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: England |
Other Details:
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Languages: eng Pagination: 814-8 Citation Subset: IM |
Affiliation:
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Service de Biochimie B, Groupe Hospitalier Necker-Enfants Malades, Paris, France. bernadette.chadefaux-vekemans@nck.ap-hop-paris.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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etiology Amniocentesis* / adverse effects Chorionic Villi Sampling* Female Humans Metabolism, Inborn Errors / diagnosis* Pregnancy Pregnancy Outcome Pregnancy Trimester, First Prenatal Diagnosis* |
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