Document Detail

Prenatal diagnosis of some metabolic diseases using early amniotic fluid samples: report of a 15 years, experience.
MedLine Citation:
PMID:  16821251     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In the present study, we report the results of 132 prenatal diagnoses performed on chorionic villi and cell-free amniotic fluid obtained simultaneously at 12-13 weeks of gestation. In addition, we report the result of 59 prenatal diagnoses performed at 12-13th week using amniotic fluid only. METHODS AND RESULTS: A total of one fetal loss (1/191) was observed when a sample of amniotic fluid was obtained at around 12-13 weeks, whereas three losses (3/82) were observed after midtrimester amniocentesis. We attribute this finding to the fact that only a very small volume of amniotic fluid was sampled using a very small needle. CONCLUSION: From these data it appears that when a couple is facing a high risk of recurrence of some metabolic diseases, the study of chorionic villus and amniotic fluid sampled simultaneously offers a safe and reliable method of early prenatal diagnosis.
B Chadefaux-Vekemans; D Rabier; N Cadoudal; A Lescoat; A Chabli; J Aupetit; Y Dumez; J F Oury
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  26     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-04     Completed Date:  2006-12-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  814-8     Citation Subset:  IM    
Service de Biochimie B, Groupe Hospitalier Necker-Enfants Malades, Paris, France.
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MeSH Terms
Abortion, Spontaneous / etiology
Amniocentesis* / adverse effects
Chorionic Villi Sampling*
Metabolism, Inborn Errors / diagnosis*
Pregnancy Outcome
Pregnancy Trimester, First
Prenatal Diagnosis*

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