Document Detail


Prenatal diagnosis of severe combined immunodeficiency with defective synthesis of HLA molecules.
MedLine Citation:
PMID:  3823004     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The immunodeficiency associated with a defective expression of HLA molecules is an autosomal recessive disorder leading to death during childhood. We have performed prenatal diagnosis for six fetuses at risk for this disease by membrane immunofluorescence on blood lymphocytes and monocytes, using specific monoclonal antibodies for HLA class I and II molecules. Two pregnancies have been found to be affected. The diagnosis has been confirmed on each abortus by the study of the membrane expression of HLA class I and II molecules on blood lymphocytes and monocytes, and on thymic and splenic cells. The four other cases were found to be normal both during pregnancy and after birth. The detection of the defect as early as the 20th week of gestation allows selective termination.
Authors:
A Durandy; N Cerf-Bensussan; Y Dumez; C Griscelli
Related Documents :
2117324 - Pregnancy-associated thrombocytopenia: definition, incidence and natural history.
15236784 - 1alpha,25-dihydroxy-vitamin-d3 as new immunotherapy in treatment of recurrent spontaneo...
16371154 - A randomised controlled trial of the effects of albendazole in pregnancy on maternal re...
35404 - Peptide contraception: antifertility properties of lh-rh analogues.
18236064 - The risk of intrapartum stillbirth among smokers of advanced maternal age.
7503174 - The effect of aspirin and indomethacin on prostacyclin and thromboxane production by pl...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  7     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1987  
Date Detail:
Created Date:  1987-03-30     Completed Date:  1987-03-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  27-34     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Female
Fetal Diseases / genetics,  immunology*
HLA Antigens / analysis*
Humans
Immunologic Deficiency Syndromes / genetics,  immunology*
Pregnancy
Pregnancy Trimester, Second
Prenatal Diagnosis*
Chemical
Reg. No./Substance:
0/HLA Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prenatal diagnosis of cystinosis utilizing chorionic villus sampling.
Next Document:  Expression of transcobalamin II by amniocytes.