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Prenatal diagnosis of non-immune hydrops fetalis: what do we tell the parents?
MedLine Citation:
PMID:  21268039     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study is to outline the aetiology and outcome of a series of fetuses with non-immune hydrops (NIH), detected prenatally. The findings are compared with a comprehensive review of recent reports.
METHODS: This is a retrospective study reviewing all pregnancies complicated by NIH in the fetus and continued after 20 weeks of pregnancy over a period of 10 years. Outcome was obtained from postmortem reports, discharge summaries, communication with the clinicians or information from the parents. A literature search was also performed to identify all reports on NIH in the last 10 years.
RESULTS: Seventy-one fetuses affected by NIH were included in this study. The aetiology of the NIH was identified prenatally in 40 cases. The most common causes of NIH were thoracic disorders, infections and cardiovascular disorders. Forty-four of the 71 (62%) fetuses were live-born. There were 10 neonatal deaths. Of the remaining 34 babies, 17 infants survived without morbidity.
CONCLUSION: The survival rate of NIH is at least 48% in this study. Prenatal identification of the cause is possible in 56% of cases. The risk of neurodevelopmental delay in those that survive is 3 of 28 (11%).
Susana Santo; Sahar Mansour; Basky Thilaganathan; Tessa Homfray; Aris Papageorghiou; Sandra Calvert; Amar Bhide
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-01-04
Journal Detail:
Title:  Prenatal diagnosis     Volume:  31     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-26     Completed Date:  2011-04-14     Revised Date:  2011-12-06    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  186-95     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 John Wiley & Sons, Ltd.
Fetal Medicine Unit, Academic Department of Obstetrics and Gynaecology, St George's Hospital Medical School, London, UK.
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MeSH Terms
Hydrops Fetalis* / diagnosis,  etiology,  mortality
Infant, Newborn
Pregnancy Outcome
Prenatal Diagnosis
Retrospective Studies

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