Document Detail

Prenatal diagnosis of methotrexate embryopathy.
MedLine Citation:
PMID:  12738117     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Methotrexate is an antineoplastic agent used by obstetrician-gynecologists for termination of early pregnancy. The drug is not always successful and is associated with a known array of malformations. CASE: We present a case of a failed pregnancy termination with methotrexate, which resulted in fetal anomalies. Ultrasound revealed absent or markedly shortened long bones, abnormal positioning of the hands, micrognathia, echogenic bowel, and a two-vessel umbilical cord. The patient elected to undergo pregnancy termination, and the ultrasound findings were confirmed at autopsy. CONCLUSION: Because of methotrexate's teratogenic potential, follow-up to confirm successful termination is necessary. Ultrasound evaluation of the fetus is indicated if pregnancy termination is unsuccessful.
Jeff B Chapa; Judith U Hibbard; Elyse M Weber; Jacques S Abramowicz; Marion S Verp
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  101     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-09     Completed Date:  2003-05-15     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1104-7     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois 60637, USA.
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MeSH Terms
Abnormalities, Drug-Induced / etiology*,  ultrasonography*
Abortifacient Agents, Nonsteroidal / adverse effects*
Abortion, Induced
Methotrexate / adverse effects*
Treatment Failure
Ultrasonography, Prenatal*
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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