Document Detail

Prenatal diagnosis and management of mainstem bronchial atresia.
MedLine Citation:
PMID:  15608465     Owner:  NLM     Status:  MEDLINE    
The prenatal diagnosis, natural history and management of mainstem bronchial atresia have not been described previously. We report two cases of prenatally diagnosed proximal bronchial atresia. The first patient presented at 18 weeks with sonographic and MRI findings consistent with bronchial atresia with fetal hydrops. The mother developed the mirror syndrome and labor was induced. A non-viable fetus was delivered at 25 weeks. The second patient presented at 16 weeks gestation with evidence of an intrathoracic mass that was subsequently prenatally diagnosed as a right mainstem bronchial atresia. The right lung increased rapidly in size and was associated with the onset of fetal hydrops. At 24 weeks, fetal pneumonectomy was performed but the fetus expired intraoperatively due to cardiovascular collapse. Post-mortem findings in both cases confirmed the presence of an atretic mainstem bronchus with massive enlargement of the lung. Bronchial atresia involving the mainstem bronchus is associated with a poor prognosis.
Sundeep G Keswani; Timothy M Crombleholme; Bruce R Pawel; Mark P Johnson; Alan W Flake; Holly L Hedrick; Lori J Howell; R Douglas Wilson; George H Davis; N Scott Adzick
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  20     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:    2005 Jan-Feb
Date Detail:
Created Date:  2004-12-20     Completed Date:  2005-04-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  74-8     Citation Subset:  IM    
Center for Fetal Diagnosis and Treatment, The Chhildren's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
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MeSH Terms
Bronchi / abnormalities*,  embryology*,  pathology
Fatal Outcome
Hydrops Fetalis / complications
Magnetic Resonance Imaging
Prenatal Diagnosis*
Respiratory System Abnormalities / complications,  diagnosis*,  embryology,  pathology,  surgery*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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