| Prenatal diagnosis and management of fetal hydrocephaly and lissencephaly. | |
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MedLine Citation:
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PMID: 8306357 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two cases of prenatal diagnosis of lissencephaly are presented in the context of a series of 118 cases of prenatally diagnosed hydrocephalus. Within this series there was one case of Walker-Warburg syndrome and another of Miller-Dieker syndrome. It is stressed that the cases reported here of ventriculomegaly diagnosed in utero show a very different outcome from those in published studies of fetal hydrocephalus which only deal with patients in whom the diagnosis was determined after birth. In those postnatal series there is a considerable selection bias, and the fate of the fetuses reported here was much worse than in postnatal series. Of the 118 fetuses 6 had fetal infections, 6 had chromosomal abnormalities, 26 had associated spina bifida, 64 fetuses had associated other anomalies, and only 28 had isolated hydrocephalus. Although it is difficult to determine the prognosis individually after prenatal diagnosis of ventriculomegaly, the data presented here may be helpful in counseling parents prenatally. The counseling should be performed with the collaboration of obstetricians, pediatricians, surgeons, and geneticists. |
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Authors:
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W Holzgreve; R Feil; F Louwen; P Miny |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery Volume: 9 ISSN: 0256-7040 ISO Abbreviation: Childs Nerv Syst Publication Date: 1993 Nov |
Date Detail:
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Created Date: 1994-03-14 Completed Date: 1994-03-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8503227 Medline TA: Childs Nerv Syst Country: GERMANY |
Other Details:
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Languages: eng Pagination: 408-12 Citation Subset: IM |
Affiliation:
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Zentrum für Frauenheilkunde Westfälische Wilhelms-Universität, Münster, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cerebral Cortex
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abnormalities* Cerebral Ventricles / ultrasonography Chromosome Aberrations / diagnosis Chromosome Disorders Corpus Callosum / abnormalities Counseling Female Fetal Diseases / diagnosis*, mortality Heart Defects, Congenital / diagnosis Humans Hydrocephalus / diagnosis*, etiology Karyotyping Pregnancy Prenatal Care Prenatal Diagnosis* Prognosis Spinal Dysraphism / complications, diagnosis Survival Rate Syndrome Toxoplasmosis / complications, diagnosis Ultrasonography, Prenatal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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