Document Detail

Prenatal diagnosis and management of congenital heart defect: significance of associated fetal anomalies and prenatal chromosome studies.
MedLine Citation:
PMID:  3893127     Owner:  NLM     Status:  MEDLINE    
A fetal cardiac defect was found prenatally by ultrasound in 13 of 230 women (5.6%) with a suspected fetal anomaly. Pregnancy duration varied between 17 and 39 weeks (mean 28 weeks). The reasons for referral of the 13 patients were: suspected fetal structural defect (n = 4), oligo- or polyhydramnios (n = 2), severe fetal growth retardation (n = 1), fetal cardiac arrhythmia (n = 1), or a combination thereof (n = 5). Abnormal chromosomes were found in 5 out of 13 fetuses (38%)-ie, four through prenatal and one through postnatal analysis. The present study demonstrates that fetal cardiac structural anomalies often are diagnosed in combination with ultrasonically established associated abnormality. Cytogenetic analysis of amniotic cells greatly improves diagnosis and obstetric management, especially when the cardiac defect per se is considered amenable to surgical treatment and other major structural defects have been ruled out.
J W Wladimiroff; P A Stewart; E S Sachs; M F Niermeijer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of medical genetics     Volume:  21     ISSN:  0148-7299     ISO Abbreviation:  Am. J. Med. Genet.     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-08-06     Completed Date:  1985-08-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7708900     Medline TA:  Am J Med Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  285-90     Citation Subset:  IM    
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MeSH Terms
Amniotic Fluid / cytology
Chromosome Aberrations / diagnosis*,  genetics
Chromosome Disorders
Congenital Abnormalities / diagnosis*,  genetics
Heart Defects, Congenital / diagnosis*,  genetics
Prenatal Diagnosis*

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