Document Detail


Prenatal diagnosis of the fragile X using thymidine induction.
MedLine Citation:
PMID:  2954037     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eleven pregnancies in ten patients at risk for the fragile X were monitored by amniocentesis or chorion villus biopsy and induction of the fragile site using thymidine, methotrexate and FUdR. Three female fetuses and one male fetus were found to have the fragile X. The results obtained using thymidine induction were superior to those using methotrexate induction and probably better than those obtained using FUdR induction.
Authors:
G R Sutherland; E Baker; S Purvis-Smith; A Hockey; E Krumins; S Z Eichenbaum
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  7     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-06-30     Completed Date:  1987-06-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  197-202     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Amniocentesis
Australia
Chorionic Villi*
Female
Floxuridine / diagnostic use
Fragile X Syndrome / diagnosis*,  epidemiology
Humans
Male
Methotrexate / diagnostic use
Pregnancy
Prenatal Diagnosis*
Sex Chromosome Aberrations / diagnosis*
Thymidine / diagnostic use
Chemical
Reg. No./Substance:
50-89-5/Thymidine; 50-91-9/Floxuridine; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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