Document Detail

Prenatal diagnosis of diffuse mesangial glomerulosclerosis by ultrasonography: a longitudinal study of a case in an affected family.
MedLine Citation:
PMID:  8838769     Owner:  NLM     Status:  MEDLINE    
The 4th child of an Arabian consanguineous family with 2 previous infant deaths due to diffuse mesangial glomerulosclerosis (at the ages of 1 and 44 days) and 1 healthy 3-year old child was followed up by ultrasonography from the 9th until the 35th week of gestation. Ultrasound showed enlarged hyperechogenic kidneys from the 14th week onwards, and the amniotic fluid level was increased to the upper normal limit. An amniocentesis at 14+ weeks of gestation showed a normal male karyotype and normal alpha-fetoprotein levels in amniotic fluid and maternal serum. Albumin and alpha 1-microglobulin levels in the amniotic fluid were within the normal range and not useful for diagnostic purposes. The child was born at the 36th week of gestation and died of renal failure 21 days later. A postmortem renal biopsy specimen revealed diffuse mesangial glomerulosclerosis.
C Hofstaetter; I Neumann; T Lennert; J W Dudenhausen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  11     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:    1996 Mar-Apr
Date Detail:
Created Date:  1996-12-03     Completed Date:  1996-12-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  126-31     Citation Subset:  IM    
Department of Gynecology and Obstetrics, Humboldt University, Berlin, Germany.
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MeSH Terms
Fatal Outcome
Follow-Up Studies
Infant, Newborn
Kidney Failure / etiology
Nephrotic Syndrome / complications,  congenital,  ethnology,  ultrasonography*
Ultrasonography, Prenatal*

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