Document Detail

Prenatal diagnosis of chromosome disorders in Tunisian population.
MedLine Citation:
PMID:  11522249     Owner:  NLM     Status:  MEDLINE    
Cytogenetic prenatal diagnosis (PND) is under national health program in most developed countries, while it concerns a small part of population at risk in developing countries. Finance is common reason of absence of PND development, but socio-cultural believes play an important role in Arab Muslim countries. In this paper we report results of 3110 fetal karyotypes carried out in a Tunisian population, by cultured amniocytes analysis. It is the largest report in a Muslim Arab country in our Knowledge. Abnormal karyotypes rate was 4.18% classified in two groups: bad prognosis (3.05%) and good prognosis (1.13%). Common amniocentesis indication was maternal age. The highest predictive value was observed in balanced karyotype and fetal ultrasound findings indications. Maternal serum markers were not commonly used for trisomy 21 screening. Pregnancy termination that is permitted by legal and religious authorities was accepted by 94,74% parents. Information about PND outcomes was given by genetic counselling prior to fetal sampling, pregnancy interruption was discussed with parents at cytogenetic result announcement. The authors conclude that in order to prevent mental and physical handicap related to cytogenetic disorders we have to promote PND by education for population, genetic counselling and fetal ultrasound screening; all three methods available in Tunisia.
H Chaabouni; M Chaabouni; F Maazoul; R M'Rad; L B Jemaa; N Smaoui; K Terras; H Kammoun; N Belghith; H Ridene; B Oueslati; F Zouari
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annales de génétique     Volume:  44     ISSN:  0003-3995     ISO Abbreviation:  Ann. Genet.     Publication Date:    2001 Apr-Jun
Date Detail:
Created Date:  2001-08-27     Completed Date:  2001-12-04     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0370562     Medline TA:  Ann Genet     Country:  France    
Other Details:
Languages:  eng     Pagination:  99-104     Citation Subset:  IM    
Service des Maladies Héréditaires et Congénitales Hôpital Charles Nicolle 1006, Tunis, Tunisia.
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MeSH Terms
Abortion, Induced
Arabs / genetics
Chromosome Banding
Chromosome Disorders / diagnosis*,  genetics,  ultrasonography
Genetic Counseling
Genetic Testing
Health Education
Maternal Age
Predictive Value of Tests
Pregnancy, High-Risk
Prenatal Diagnosis*

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