| Prenatal diagnosis of cardiac rhabdomyomas: incidence of associated cerebral lesions of tuberous sclerosis complex. | |
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MedLine Citation:
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PMID: 19606448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To determine the prevalence of specific cerebral lesions of tuberous sclerosis complex (TSC) and neurological outcome in cases diagnosed prenatally with cardiac rhabdomyomas. METHODS: We reviewed all fetuses diagnosed prenatally with cardiac rhabdomyomas which had undergone detailed ultrasound evaluation and cerebral magnetic resonance imaging (MRI) and which were recorded in the database of a single institution covering the period January 1992 to December 2005. RESULTS: Fifty-one fetuses were included in the study. MRI was performed at a mean +/- SD gestational age of 30 +/- 3 gestational weeks and showed specific lesions of TSC in 49% of cases. Termination of pregnancy was chosen by the parents in 26 cases. Neurological development was studied in 20 cases, follow-up lasting 4.8 +/- 2.9 years. Neurodevelopmental events occurred during the follow-up period in 45% of cases. Neurological complications occurred in 67% of patients who had cerebral lesions at MRI and in 33% of patients with normal MRI results. There was no significant difference between the two groups of patients (P = 0.2). CONCLUSION: In fetuses with cardiac rhabdomyomas detailed ultrasound examination and third-trimester cerebral MRI are able to diagnose most TSC cerebral lesions, but fail to determine neurological outcome. |
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Authors:
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J Saada; S Hadj Rabia; L Fermont; J Le Bidois; L S Bernardes; L Bernades-Stein; J Martinovic; P Sonigo; Y Dumez; D Bonnet; A Benachi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Volume: 34 ISSN: 1469-0705 ISO Abbreviation: Ultrasound Obstet Gynecol Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-08-05 Completed Date: 2010-08-19 Revised Date: 2010-08-24 |
Medline Journal Info:
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Nlm Unique ID: 9108340 Medline TA: Ultrasound Obstet Gynecol Country: England |
Other Details:
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Languages: eng Pagination: 155-9 Citation Subset: IM |
Affiliation:
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Maternité, Université Paris-Descartes, Faculté de Médecine, AP-HP, Hôpital Necker-Enfants Malades, Paris, France. juliensaada@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Genetic Counseling Gestational Age Heart Neoplasms / diagnosis*, genetics Humans Incidence Magnetic Resonance Imaging Mental Retardation / genetics* Pregnancy Prenatal Diagnosis Prognosis Rhabdomyoma / diagnosis*, genetics Tuberous Sclerosis / diagnosis*, genetics, ultrasonography Ultrasonography, Prenatal Young Adult |
| Comments/Corrections | |
Erratum In:
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Ultrasound Obstet Gynecol. 2009 Oct;34(4):489 Note: Bernades-Stein L [corrected to Bernardes, L S] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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