|Prenatal diagnosis by echocardiogram and outcome of absent pulmonary valve syndrome.|
|PMID: 12586257 Owner: NLM Status: MEDLINE|
|We reported echocardiographic findings and outcomes of fetuses with absent pulmonary valve syndrome diagnosed during fetal life. Cases were identified from a prospectively acquired computerized database of 18,308 pregnancies referred to a fetal cardiology center between January 1988 and July 2000. Twenty fetuses were identified with a median gestation of 23 weeks (range 18 to 36) at presentation. In 18 cases (90%), there was an associated ventricular septal defect. Eighteen cases (90%) had branch pulmonary artery diameters above the normal range. In four cases (20%), an arterial duct was present. A chromosome 22q11 deletion was identified in 2 of 9 cases (22%) in which this deletion was sought. There were 6 terminations of pregnancy (30%), 3 intrauterine deaths (15%), 5 neonatal deaths (25%), 3 infant deaths (15%), and 3 patients who did not die (15%). Ten of the 11 "liveborn" infants required early ventilation. The outcome of absent pulmonary valve syndrome diagnosed prenatally appears poor. The high morbidity and mortality is due to both cardiac disease and associated bronchomalacia.|
|Reza S Razavi; Gurleen K Sharland; John M Simpson|
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|Type: Journal Article|
|Title: The American journal of cardiology Volume: 91 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2003 Feb|
|Created Date: 2003-02-14 Completed Date: 2003-03-13 Revised Date: 2004-11-17|
Medline Journal Info:
|Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States|
|Languages: eng Pagination: 429-32 Citation Subset: AIM; IM|
|Fetal Cardiology Unit, Department of Congenital Heart Disease, Guy's Hospital, London, United Kingdom.|
|APA/MLA Format Download EndNote Download BibTex|
Chromosomes, Human, Pair 22 / genetics
Echocardiography / methods*
Fetal Death / etiology
Heart Septal Defects, Ventricular / genetics, mortality, therapy, ultrasonography*
Intensive Care, Neonatal
Pulmonary Atresia / genetics, mortality, therapy, ultrasonography*
Ultrasonography, Prenatal / methods*
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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