Document Detail

Prenatal diagnosis of Meckel syndrome: alpha-feto protein and beta-trace protein in amniotic fluid.
MedLine Citation:
PMID:  66999     Owner:  NLM     Status:  MEDLINE    
Meckel syndrome was diagnosed prenatally by alpha-feto protein and beta-trace protein determinations in amniotic fluid. No central nervous system anomalies were detected in the affected fetus, who presented with large polycystic kidneys and polydactyly. An excessive synthesis of these fetal proteins by the dysplastic kidneys is suggested, allowing for the possibility of prenatal diagnosis of polycystic kidneys in families at risk for this disease. The present family emphasized the importance of amniocentesis in pregnancies at risk for Meckel syndrome, regardless of the presence of a defect in neural tube closure.
J Chemke; A Miskin; Z Rav-Acha; A Porath; M Sagiv; Z Katz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical genetics     Volume:  11     ISSN:  0009-9163     ISO Abbreviation:  Clin. Genet.     Publication Date:  1977 Apr 
Date Detail:
Created Date:  1977-06-11     Completed Date:  1977-06-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0253664     Medline TA:  Clin Genet     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  285-9     Citation Subset:  IM    
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MeSH Terms
Abnormalities, Multiple / genetics
Amniotic Fluid / analysis*
Beta-Globulins / analysis*
Encephalocele / diagnosis*,  genetics
Fingers / abnormalities*
Polycystic Kidney Diseases / diagnosis*,  genetics
Prenatal Diagnosis*
Toes / abnormalities*
alpha-Fetoproteins / analysis*
Reg. No./Substance:
0/Beta-Globulins; 0/alpha-Fetoproteins

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