Document Detail

Prenatal detection of associated anomalies in fetuses diagnosed with cleft lip with or without cleft palate in utero.
MedLine Citation:
PMID:  16247756     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to determine the prenatal detection rate of associated anomalies in fetuses with a suspected cleft lip with or without cleft palate. METHODS: Fetuses with a suspected cleft lip with or without cleft palate, determined by prenatal ultrasound, were prospectively enrolled. Additional anomalies suspected by ultrasound or genetic testing were recorded. Postnatal outcome was obtained. RESULTS: Forty-five fetuses with a cleft lip with or without cleft palate, diagnosed prenatally with either two-dimensional and/or three-dimensional ultrasound, were studied. Postnatal follow-up revealed that 16 (35.6%) of these 45 fetuses had an additional structural or syndromic abnormality. Of the 37 fetuses with prenatally determined 'isolated' cleft lip with or without cleft palate, eight (21.6%) had an additional malformation identified after delivery. CONCLUSION: In pregnancies complicated by a cleft lip with or without cleft palate, patients should be informed of the risks of associated anomalies, some of which may be undetected prenatally.
R Chmait; D Pretorius; T Moore; A Hull; G James; T Nelson; M Jones
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  27     ISSN:  0960-7692     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-31     Completed Date:  2006-12-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  173-6     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2005 ISUOG.
Florida Institute for Fetal Diagnosis and Therapy, Tampa, FL, USA.
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MeSH Terms
Abnormalities, Multiple / ultrasonography*
Cleft Lip / ultrasonography*
Cleft Palate / ultrasonography
Fetal Diseases / ultrasonography*
Fetus / abnormalities*
Pregnancy Outcome
Prospective Studies
Ultrasonography, Prenatal / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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