| Prenatal course and outcome in 103 cases of fetal spina bifida: a single center experience. | |
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MedLine Citation:
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PMID: 20846060 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the prenatal course and functional outcome for fetuses with spina bifida according to the level of the spinal lesion at prenatal ultrasound examination. DESIGN: Retrospective, descriptive study. SETTING: Tertiary referral center, Germany. POPULATION: A total of 103 fetuses with spina bifida identified between 1993 and 2008. METHODS: The antenatal course and postnatal outcome for affected fetuses were reviewed. The relation of relevant outcome domains to the anatomical level was assessed using Fisher's exact test and the χ(2)-test. MAIN OUTCOME MEASURES: Level and type of spinal lesion, pregnancy outcome, psychomotor development, bladder and bowel function. RESULTS: Our cohort included a total of 31 live born infants, 68 terminated pregnancies, four intrauterine fetal deaths and five postnatal deaths. Four cases were excluded from follow-up. Twenty of the remaining 22 infants had normal or only slightly impaired mental development (91%). Thirteen children (59%) were able to walk, but nine (41%) needed wheelchairs or were paraplegic. The rate of poor motor outcome varied strongly in dependence on the level of the lesion (22.2% at lower lumbosacral levels to 80% at thoracic level). The majority of the affected children (16/22, 72.7%) suffered from impairment of bladder function. In 36% of cases (8/22) anal incontinence was documented. CONCLUSION: Spina bifida can result in a spectrum of disabilities that frequently lead to an impairment of bladder, bowel and motor function. The motor function depended on level of the lesion. |
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Authors:
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Feriel Amari; Wiebe Junkers; David Hartge; Daniel Alexander Beyer; Roland Axt-Fliedner; Jan Weichert |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta obstetricia et gynecologica Scandinavica Volume: 89 ISSN: 1600-0412 ISO Abbreviation: Acta Obstet Gynecol Scand Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-17 Completed Date: 2010-09-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: England |
Other Details:
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Languages: eng Pagination: 1276-83 Citation Subset: IM |
Affiliation:
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Division of Prenatal Medicine, University Clinic of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany. feriel.amari@uk-sh.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Fecal Incontinence
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etiology Female Humans Infant Infant, Newborn Male Nervous System Diseases / etiology Outcome Assessment (Health Care) Pregnancy Pregnancy Outcome Retrospective Studies Spinal Dysraphism / complications*, ultrasonography* Ultrasonography, Prenatal Urination Disorders / etiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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