| Prenatal cortisol exposure predicts infant cortisol response to acute stress. | |
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MedLine Citation:
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PMID: 22315044 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Experimental animal findings suggest that early stress and glucocorticoid exposure may program the function of the hypothalamic-pituitary-adrenal (HPA) axis in the offspring. The extension of these findings to human development is not yet clear. A prospective longitudinal study was conducted on 125 mothers and their normally developing children. Amniotic fluid was obtained at, on average, 17.2 weeks gestation; infant behavior and cortisol response to a separation-reunion stress was assessed at 17 months. Amniotic fluid cortisol predicted infant cortisol response to separation-reunion stress: infants who were exposed to higher levels of cortisol in utero showed higher pre-stress cortisol values and blunted response to stress exposure. The association was independent of prenatal, obstetric, and socioeconomic factors and child-parent attachment. The findings provide some of the strongest data in humans that HPA axis functioning in the child may be predicted from prenatal cortisol exposure. © 2012 Wiley Periodicals, Inc. Dev Psychobiol. |
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Authors:
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Thomas G O'Connor; Kristin Bergman; Pampa Sarkar; Vivette Glover |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-7 |
Journal Detail:
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Title: Developmental psychobiology Volume: - ISSN: 1098-2302 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0164074 Medline TA: Dev Psychobiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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Department of Psychiatry, Wynne Center for Family Research, University of Rochester Medical Center, 300 Crittenden Blvd, Rochester, New York 14642. tom_oconnor@urmc.rochester.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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