Document Detail


Prenatal cocaine exposure and prematurity: neurodevelopmental growth.
MedLine Citation:
PMID:  10972249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The consequences of prematurity and prenatal cocaine exposure on early neurobehavior and physical growth were examined longitudinally in a sample of 20 cocaine-exposed and 20 non-exposed preterm neonates. The magnitude of the difference in physical growth acceleration related to prenatal cocaine exposure increased with increasing birth gestational age, whereas growth rate differences in irritability decreased. In contrast, prenatal cocaine exposure, independent of prematurity, was related to reduced attention skills at 36 weeks conceptional age and increased rates of neurobehavioral change. The effects of prenatal cocaine exposure differed with respect to the degree of prematurity, depending on the nature of the outcome examined, suggesting differing windows of vulnerability for different outcome domains. The usefulness of a developmental growth perspective was demonstrated.
Authors:
K Andrews; D J Francis; M L Riese
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of developmental and behavioral pediatrics : JDBP     Volume:  21     ISSN:  0196-206X     ISO Abbreviation:  J Dev Behav Pediatr     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2001-02-02     Completed Date:  2001-02-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8006933     Medline TA:  J Dev Behav Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  262-70     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Southern Illinois University School of Medicine, Carbondale, Illinois 62901-6503, USA. kespy@siumed.edu
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MeSH Terms
Descriptor/Qualifier:
Arousal / drug effects
Attention / drug effects
Cocaine / adverse effects*
Developmental Disabilities / chemically induced*,  diagnosis
Female
Gestational Age
Humans
Infant, Newborn
Infant, Premature, Diseases / chemically induced*,  diagnosis
Longitudinal Studies
Neurologic Examination / drug effects
Pregnancy
Prenatal Exposure Delayed Effects*
Risk Factors
Grant Support
ID/Acronym/Agency:
HD-22637/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
50-36-2/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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