| Prenatal cocaine exposure. A longitudinal study of development. | |
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MedLine Citation:
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PMID: 9668403 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The current study examines the effect of prenatal cocaine use on physical, cognitive, and behavioral development at birth, 1, 3, and 7 years, controlling for other factors that affect child development. Women who used cocaine during pregnancy were more likely to be single and to use alcohol, marijuana, and tobacco than were women who did not use cocaine. Prenatal cocaine use was associated with reduced gestational age, but not with birth weight, length, or head circumference. Neonatal neurobehavioral assessments were affected by prenatal cocaine exposure. Growth at 1 year was not affected by prenatal cocaine use. At 3 years, prenatal cocaine use was a significant predictor of head circumference and of the composite score on the Stanford-Binet Intelligence Scale (4th edition). Prenatal cocaine use was also associated with temperamental differences at 1 and 3 years and with behavior problems at 3 years. These findings represent a pattern of central nervous system effects, related to prenatal cocaine exposure, which is predicted by the teratologic model. |
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Authors:
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G A Richardson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 846 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-07-31 Completed Date: 1998-07-31 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 144-52 Citation Subset: IM |
Affiliation:
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Western Psychiatric Institute & Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA. gar + @pitt.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Birth Weight Body Constitution Brain / growth & development Child Development* Cocaine* Cognition* Electroencephalography Female Gestational Age Growth* Humans Infant, Newborn Longitudinal Studies Pregnancy Prenatal Exposure Delayed Effects* Socioeconomic Factors Substance-Related Disorders* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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DA05460/DA/NIDA NIH HHS; DA06839/DA/NIDA NIH HHS; DA08916/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-36-2/Cocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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