Document Detail

Prenatal cocaine exposure and infant cortisol reactivity.
MedLine Citation:
PMID:  19467009     Owner:  NLM     Status:  MEDLINE    
This study examined the effects of prenatal cocaine exposure on infant hypothalamic-pituitary-adrenal axis activity and reactivity at 7 months of infant age. Participants were 168 caregiver-infant dyads (87 cocaine exposed, 81 not cocaine exposed; 47% boys). Maternal behavior, caregiving instability, and infant growth and behavior were assessed, and children's saliva was sampled before, during, and after standardized procedures designed to elicit emotional arousal. Results revealed cocaine-exposed infants had a high amplitude trajectory of cortisol reactivity compared to non-cocaine-exposed infants. Infant gender and caregiving instability moderated this association. The findings support a dual hazard vulnerability model and have implications for evolutionary-developmental theories of individual differences in biological sensitivity to context.
Rina D Eiden; Yvette Veira; Douglas A Granger
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Child development     Volume:  80     ISSN:  1467-8624     ISO Abbreviation:  Child Dev     Publication Date:    2009 Mar-Apr
Date Detail:
Created Date:  2009-05-26     Completed Date:  2009-09-22     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  0372725     Medline TA:  Child Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  528-43     Citation Subset:  IM    
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MeSH Terms
Case-Control Studies
Child Development / drug effects*
Cocaine / administration & dosage*,  toxicity*
Hydrocortisone / metabolism*
Hypothalamo-Hypophyseal System / drug effects,  metabolism
Pituitary-Adrenal System / drug effects,  metabolism
Prenatal Exposure Delayed Effects*
Saliva / chemistry,  drug effects
Grant Support
1R01DA013190/DA/NIDA NIH HHS; R01 DA013190/DA/NIDA NIH HHS; R01 DA013190-07/DA/NIDA NIH HHS
Reg. No./Substance:
I5Y540LHVR/Cocaine; WI4X0X7BPJ/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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