| Prenatal cocaine exposure and BMI and blood pressure at 9 years of age. | |
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MedLine Citation:
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PMID: 20486281 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Prenatal cocaine exposure has been linked to intrauterine growth retardation and poor birth outcomes; little is known about the effects on longer-term medical outcomes, such as overweight status and hypertension in childhood. Our objective was to examine the association between prenatal cocaine exposure and BMI and blood pressure at 9 years of age among children followed prospectively in a multisite longitudinal study evaluating the impact of maternal lifestyle during pregnancy on childhood outcome. DESIGN/METHODS: This analysis includes 880 children (277 cocaine exposed and 603 with no cocaine exposure) with blood pressure, height, and weight measurements at 9 years of age. Regression analyses were conducted to explore the relationship between prenatal cocaine exposure and BMI and blood pressure at 9 years of age after controlling for demographics, other drug exposure, birthweight, maternal weight, infant postnatal weight gain, and childhood television viewing, exercise, and dietary habits at 9 years. Path analyses were used to further explore these relationships. RESULTS: At 9 years of age, 15% of the children were prehypertensive and 19% were hypertensive; 16% were at risk for overweight status and 21% were overweight. A small percentage of women were exposed to high levels of prenatal cocaine throughout pregnancy. A higher BMI was noted in children born to these women. Path analysis suggested that high cocaine exposure has an indirect effect on systolic and diastolic blood pressures that is mediated through its effect on BMI. CONCLUSION: High levels of in-utero cocaine exposure are a marker for elevated BMI and blood pressure among children born full term. |
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Authors:
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Seetha Shankaran; Carla M Bann; Charles R Bauer; Barry M Lester; Henrietta S Bada; Abhik Das; Rosemary D Higgins; W Kenneth Poole; Linda L LaGasse; Jane Hammond; Eunice Woldt |
Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of hypertension Volume: 28 ISSN: 1473-5598 ISO Abbreviation: J. Hypertens. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-19 Completed Date: 2010-08-16 Revised Date: 2011-11-18 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 1166-75 Citation Subset: IM |
Affiliation:
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Wayne State University School of Medicine, Detroit, Michigan, USA. sshankar@med.wayne.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure* Body Mass Index* Child Cocaine / administration & dosage* Energy Intake Exercise Female Humans Longitudinal Studies Male Pregnancy Prenatal Exposure Delayed Effects* |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR16587/RR/NCRR NIH HHS; N01 HD23159/HD/NICHD NIH HHS; U10 HD021385-23/HD/NICHD NIH HHS; U10 HD21385/HD/NICHD NIH HHS; U10 HD21397/HD/NICHD NIH HHS; U10 HD27904/HD/NICHD NIH HHS; U10 HD36790/HD/NICHD NIH HHS; U10 HD42638/HD/NICHD NIH HHS; U10HD21385/HD/NICHD NIH HHS; U10HD21397/HD/NICHD NIH HHS; U10HD36790/HD/NICHD NIH HHS; U10HD42638/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-36-2/Cocaine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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