Document Detail

Prenatal cigarette smoke exposure attenuates recovery from hypoxemic challenge in preterm infants.
MedLine Citation:
PMID:  18565950     Owner:  NLM     Status:  MEDLINE    
RATIONALE: The effects of prenatal cigarette smoke (CS) exposure and hypoxemia on cardiorespiratory control have been investigated in full-term infants. However, few data are available in preterm infants, who form a particularly vulnerable population, with developmentally immature cardiorespiratory control.
OBJECTIVES: To investigate the effects of prenatal CS exposure on the duration and recovery of breathing pauses and oxygen saturation levels under baseline and hypoxemic conditions in preterm infants.
METHODS: The study was performed on 22 (12 born to smoking and 10 to nonsmoking mothers) spontaneously breathing preterm infants between 28 and 36 weeks' gestation. Cardiorespiratory variables were recorded under baseline normoxemic and hypoxemic conditions.
MEASUREMENTS AND MAIN RESULTS: Breathing pauses, pause indices, time to recovery, percent pause recovery, oxygen saturation (Sp(O2)), periods of wakefulness, and cardiorespiratory rates were compared between the two groups. Spontaneous recovery of breathing pauses (P = 0.03) and Sp(O(2)) levels (P = 0.017) were attenuated in CS-exposed infants as compared with the control group during the hypoxemic and posthypoxemic periods, respectively. The episodes of wakefulness during the hypoxemic challenge were similar between the two groups. Furthermore, CS-exposed infants showed a greater increase in heart rate (P < 0.001) during the hypoxemic challenge when compared with control infants.
CONCLUSIONS: We provide evidence of how prenatal CS exposure and hypoxemic episodes affect the duration and recovery of breathing pauses in preterm infants. These observations could help explain why these infants are at a particularly high risk for sudden infant death syndrome.
Jennifer Schneider; Ian Mitchell; Nalini Singhal; Valerie Kirk; Shabih U Hasan
Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-19
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  178     ISSN:  1535-4970     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-20     Completed Date:  2008-09-16     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  520-6     Citation Subset:  AIM; IM    
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MeSH Terms
Analysis of Variance
Anoxia / physiopathology*
Apnea / physiopathology*
Heart Rate
Infant, Newborn
Infant, Premature*
Oxygen / metabolism*
Prenatal Exposure Delayed Effects*
Remission, Spontaneous
Respiratory Function Tests
Smoking / adverse effects*
Sudden Infant Death
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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