Document Detail

Prenatal caffeine assessment: fetal and maternal biomarkers or self-reported intake?
MedLine Citation:
PMID:  18083538     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We sought to examine associations among measures of caffeine exposure, including maternal urine, umbilical cord blood, and maternal self report.
METHODS: Pregnant women were recruited from 56 obstetric practices and 15 clinics associated with six hospitals in Connecticut and Massachusetts between September 1996 and January 2000; 3633 women were enrolled. Maternal urine throughout pregnancy and umbilical cord blood samples were analyzed for caffeine, paraxanthine, theophylline, and theobromine. Maternal caffeine intake was assessed throughout pregnancy.
RESULTS: Urinary and cord blood biomarkers were correlated with reported intake throughout pregnancy (range r = 0.35-0.66; p < 0.0001). Infants of smokers had greater cord blood concentrations of paraxanthine, reflecting faster caffeine metabolism in smokers, and cord blood paraxanthine levels were more strongly correlated with intake in smokers.
CONCLUSION: Maternal self reported intake may still be the optimal and most valid measure of antenatal caffeine exposure, since biomarkers do not reflect exposure over pregnancy.
Laura M Grosso; Elizabeth Triche; Neal L Benowitz; Michael B Bracken
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Annals of epidemiology     Volume:  18     ISSN:  1047-2797     ISO Abbreviation:  Ann Epidemiol     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-18     Completed Date:  2008-06-03     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  9100013     Medline TA:  Ann Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  172-8     Citation Subset:  IM    
Yale Center for Perinatal, Pediatric and Environmental Epidemiology, Yale University School of Medicine, Department of Epidemiology and Public Health, One Church Street, New Haven, CT 06510, USA. <>
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MeSH Terms
Biological Markers / blood,  urine
Caffeine / administration & dosage*,  blood,  urine
Fetal Blood / metabolism
Maternal-Fetal Exchange
Pregnancy / blood,  urine
Pregnancy Outcome
Grant Support
R01 AI 041040-06A2/AI/NIAID NIH HHS; R01 AI041040/AI/NIAID NIH HHS; R01 AI041040-06A2/AI/NIAID NIH HHS; R01 DA/HD05484-11A1/DA/NIDA NIH HHS; R01 DA005484/DA/NIDA NIH HHS; R01 DA005484-11A1/DA/NIDA NIH HHS
Reg. No./Substance:
0/Biological Markers; 58-08-2/Caffeine

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