Document Detail

Prenatal buprenorphine exposure: effects on biochemical markers of hypoxia and early neonatal outcome.
MedLine Citation:
PMID:  18951215     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the possible association between prenatal buprenorphine exposure and compromised early neonatal outcome in view of markers of perinatal hypoxia. DESIGN, SETTING AND SAMPLE: The study group consisted of 27 full-term neonates exposed to buprenorphine prenatally and prospectively followed up at a special tertiary outpatient clinic for pregnant drug abusers. Serving as controls were 27 full-term neonates exposed prenatally to illicit substances other than opioids and 38 full-term neonates from uncomplicated pregnancies of healthy parturients. METHODS AND MAIN OUTCOME MEASURES: Apgar scores, cord pH and base excess were recorded. Cord serum samples were collected at birth for analysis of biochemical markers of fetal hypoxic stress: erythropoietin (EPO; chronic hypoxia), cardiac troponin T (cardiac involvement) and S100 (neural damage). RESULTS: All infants were born in good condition according to Apgar scores and pH of cord blood. No statistically significant differences were found between the three groups in cord serum concentrations of EPO (33.0 median, range: 9.0-476.0 U/L in the buprenorphine-exposed group vs 27.0, range: 8.0-114.0 U/L in substance-abusing controls vs 28.1, range: 11.6-260.0 U/L in healthy controls) or S100 (0.47, range: 0.25-0.91 microg/L vs 0.40, range: 0.12-1.22 microg/L vs 0.47, range: 0.20-2.15 microg/L). No significant differences existed in cardiac TnT levels (0.017, range: 0.010-0.072 U/L vs 0.010, range: 0.010-0.075 U/L vs 0.024, range: 0.010-0.075 U/L). CONCLUSIONS: While no significant differences in asphyxia markers were observed between the three groups, a tendency towards higher levels of EPO emerged in the buprenorphine-exposed group.
Hanna Kahila; Vedran Stefanovic; Mikko Loukovaara; Henrik Alfthan; Esa Hämäläinen; Erja Halmesmäki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  87     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2008  
Date Detail:
Created Date:  2008-11-21     Completed Date:  2008-12-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1213-9     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Women's Clinic Laboratory, Helsinki University Central Hospital, Helsinki, Finland.
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MeSH Terms
Acid-Base Equilibrium / drug effects,  physiology
Apgar Score
Biological Markers / blood
Buprenorphine / adverse effects*
Case-Control Studies
Dose-Response Relationship, Drug
Erythropoietin / blood
Fetal Blood / chemistry
Fetal Hypoxia / blood*,  chemically induced,  epidemiology
Follow-Up Studies
Infant, Newborn
Narcotics / adverse effects*
Pregnancy Outcome*
Prenatal Exposure Delayed Effects*
Prospective Studies
S100 Proteins / blood
Troponin T / blood
Young Adult
Reg. No./Substance:
0/Biological Markers; 0/Narcotics; 0/S100 Proteins; 0/Troponin T; 11096-26-7/Erythropoietin; 52485-79-7/Buprenorphine

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