Document Detail

Prenatal biochemical screening for neural tube defects.
MedLine Citation:
PMID:  12861422     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Neural tube defects (NTDs) can be considered as a folate deficiency disorder. The prevalence of NTDs ranges from about 0.5 to 6 in 1,000 births. DISCUSSION: Two steps can be distinguished in biochemical screening for NTDs: 1. Screening in the general population, which is based on two complementary methods, maternal serum AFP screening and ultrasound screening; 2. Screening in a high-risk group, which requires fetal scanning by an expert sonographer. CONCLUSION: Amniocentesis for acetylcholinesterase electrophoresis is indicated when sonographic scans are difficult to interpret.
Françoise Muller
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2003-07-12
Journal Detail:
Title:  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery     Volume:  19     ISSN:  0256-7040     ISO Abbreviation:  Childs Nerv Syst     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-09-04     Completed Date:  2003-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8503227     Medline TA:  Childs Nerv Syst     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  433-5     Citation Subset:  IM    
Laboratoire de Biochimie, Hôpital Ambroise Paré, 9 Avenue du Général de Gaulle, 92104 Boulogne Cedex, France.
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MeSH Terms
Amniotic Fluid / metabolism
Biochemistry / methods*
Mass Screening*
Neural Tube Defects / diagnosis*,  epidemiology
Prenatal Diagnosis*
alpha-Fetoproteins / analysis
Reg. No./Substance:

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