| Prenatal behavior of the C57BL/6J mouse: a promising model for human fetal movement during early to mid-gestation. | |
| | |
MedLine Citation:
|
PMID: 18980217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The study of fetal neurobehavioral development in genetically altered mice promises a significant advance in our understanding of the prenatal origins of developmental disabilities in humans. Despite their importance, little is known about fetal neurobehavioral development in mice. In this study, we observed prenatal behavioral patterns of the C57BL/6J mouse, a common background strain for genetically altered mice, and report their similarity to those observed in the early to mid-gestation human fetus. Fetal offspring from pregnant C57BL/6J dams were observed on the day before birth (E18 of a 19-day gestation). Scoring and analysis of fetal movement included Prechtl's Method for Qualitative Assessment, Interlimb Movement Synchrony, a measure of the temporal relationship between movements of limb pairs, and Behavioral State, quantified through detailed analysis of high and low amplitude limb movements. With the exception of fetal breathing movements, all categories and patterns of behavior typically reported in the early to mid-gestation human fetus were observed in the C57BL/6J mouse fetus. Our results suggest that behavioral analysis of fetal C57BL/6J mice may yield important new insights into early to mid-gestation human behavioral development. |
| | |
Authors:
|
Gale A Kleven; April E Ronca |
Related Documents
:
|
6631847 - Life-threatening fetal anemia secondary to fetal-maternal hemorrhage. a case report. 11534297 - Fetal ethology and its relevance to perinatal medicine. 7418637 - Regular and irregular human fetal respiratory movement. 4653877 - Detection of fetal heart movement in first trimester of pregnancy using pulsed ultrasound. 9619567 - Characteristic changes of large granular lymphocytes that strongly express cd56 in endo... 13130447 - Rapidly growing sublingual dermoid cyst throughout pregnancy. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Developmental psychobiology Volume: 51 ISSN: 1098-2302 ISO Abbreviation: Dev Psychobiol Publication Date: 2009 Jan |
Date Detail:
|
Created Date: 2008-12-29 Completed Date: 2009-04-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0164074 Medline TA: Dev Psychobiol Country: United States |
Other Details:
|
Languages: eng Pagination: 84-94 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. gkleven@wfubmc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Disease Models, Animal* Extremities / embryology Female Fetal Development / physiology* Gestational Age Humans Mice Mice, Inbred C57BL Movement / physiology Pregnancy |
| Grant Support | |
ID/Acronym/Agency:
|
K99NR010798/NR/NINR NIH HHS; R01HD50201/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: TGF-beta1 induces rearrangement of FLK-1-VE-cadherin-beta-catenin complex at the adherens junction t...
Next Document: Familial dyskinesia and facial myokymia (FDFM): Follow-up of a large family and linkage to chromosom...