Document Detail

Prenatal animal contact and gene expression of innate immunity receptors at birth are associated with atopic dermatitis.
MedLine Citation:
PMID:  21112617     Owner:  NLM     Status:  In-Process    
BACKGROUND: Cross-sectional studies have suggested that prenatal farm exposures might protect against allergic disease and increase the expression of receptors of the innate immune system. However, epidemiologic evidence supporting the association with atopic dermatitis remains inconsistent.
OBJECTIVE: To study the association between prenatal farm-related exposures and atopic dermatitis in a prospective study. We further analyzed the association between the expression of innate immune genes at birth and atopic dermatitis.
METHODS: A total of 1063 children who participated in a birth cohort study, Protection against Allergy-Study in Rural Environments, were included in this study. Doctor diagnosis of atopic dermatitis was reported by the parents from 1 to 2 years of age by questionnaire. Gene expression of Toll-like receptors (TLRs) and CD14 was assessed in cord blood leukocytes by quantitative PCR.
RESULTS: Maternal contact with farm animals and cats during pregnancy had a significantly protective effect on atopic dermatitis in the first 2 years of life. The risk of atopic dermatitis was reduced by more than half among children with mothers having contact with 3 or more farm animal species during pregnancy compared with children with mothers without contact (adjusted odds ratio, 0.43; 95% CI, 0.19-0.97). Elevated expression of TLR5 and TLR9 in cord blood was associated with decreased doctor diagnosis of atopic dermatitis. A significant interaction between polymorphism in TLR2 and prenatal cat exposure was observed in atopic dermatitis.
CONCLUSION: Maternal contact with farm animals and cats during pregnancy has a protective effect on the development of atopic dermatitis in early life, which is associated with a lower expression of innate immune receptors at birth.
Caroline Roduit; Johanna Wohlgensinger; Remo Frei; Sondhja Bitter; Christian Bieli; Susanne Loeliger; Gisela Büchele; Josef Riedler; Jean-Charles Dalphin; Sami Remes; Marjut Roponen; Juha Pekkanen; Michael Kabesch; Bianca Schaub; Erika von Mutius; Charlotte Braun-Fahrländer; Roger Lauener;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-11-26
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  127     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  179-85, 185.e1     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
University of Zurich, Children's Hospital, and Christine Kühne-Center for Allergy Research and Education, Zurich, Switzerland.
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MeSH Terms
Gertraud Weiss / ; Ellen Üblagger / ; Claudia Humer / ; Manuela Russegger / ; Raija Juntunen / ; Reetta Tiihonen / ; Pekka Tiittanen / ; Kati Huttunen / ; Suvi Virtanen / ; Timo Kauppila / ; Aino Nevalainen / ; Tomi-Pekka Tuomainen / ; Anne Karvonen / ; Mikko Lappalainen / ; Marie-Laure Dalphin / ; Dominique Vuitton / ; Renaud Piarroux / ; Gabriel Reboux / ; Sandrine Roussel / ; Bertrand Sudre / ; Susanne Schmid / ; Sabina Illi / ; Nicola Korherr / ; Jon Genuneit / ; Richard Peter / ; Serdar Sel / ; Nicole Blümer / ; Petra Pfefferle / ; Harald Renz / ; Bert Brunekreef / ; Ulrike Gehring / ; Gert Dockes / ; Felix H Sennhauser /

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