| Prenatal alcohol exposure and language delay in 2-year-old children: the importance of dose and timing on risk. | |
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MedLine Citation:
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PMID: 19171621 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of this study was to investigate the association of dose and timing of prenatal alcohol exposure with early language acquisition. METHODS: We examined language delay in a randomly selected, population-based sample of Western Australian children born in 1995-1996 whose mothers had agreed to participate in a longitudinal study on health-related behaviors and who had completed the 2-year questionnaire (N = 1739). Information on alcohol consumption was collected at 3 months after birth for four periods; the three months pre-pregnancy and for each trimester separately. Prenatal alcohol exposure was grouped into none, low, moderate-heavy and binge (>5) based on the total quantity consumed per week, quantity consumed per occasion, and frequency of consumption. The communication scale from the Ages & Stages Questionnaire was used to evaluate language delay. Logistic regression analysis was used to generate odds ratios and 95% confidence intervals, adjusted for confounding factors. RESULTS: There was no association between low levels of alcohol consumption and language delay at any time period, although there was a nonsignificant 30% increase in risk when moderate-to-heavy levels of alcohol were consumed in the third trimester. Children exposed to a binge pattern of maternal alcohol consumption in the second trimester had nonsignificant, three-fold increased odds of language delay, with a similar estimate following third trimester alcohol exposure after controlling for covariates. CONCLUSIONS: This study did not detect an association between low levels of prenatal alcohol exposure and language delay when compared with women who abstained from alcohol during pregnancy. A nonsignificant threefold increase in the likelihood of language delay was seen in children whose mothers binged during late pregnancy. However, the small numbers of women with a binge-drinking pattern in late pregnancy limited the power of this study; studies analyzing larger numbers of children exposed to binge drinking in late pregnancy are needed. |
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Authors:
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Colleen O'Leary; Stephen R Zubrick; Catherine L Taylor; Glenys Dixon; Carol Bower |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatrics Volume: 123 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-27 Completed Date: 2009-03-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
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Languages: eng Pagination: 547-54 Citation Subset: AIM; IM |
Affiliation:
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Division of Population Sciences, Telethon Institute for Child Health Research, PO Box 855, West Perth, WA 6872, Australia. colleeno@ichr.uwa.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alcohol Drinking / epidemiology* Child, Preschool Female Humans Language Development Disorders / etiology* Pregnancy Prenatal Exposure Delayed Effects / epidemiology* Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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