| Prenatal alcohol exposure and attention, learning and intellectual ability at 14 years: a prospective longitudinal study. | |
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MedLine Citation:
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PMID: 16842939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A range of adverse birth outcomes is associated with heavy prenatal alcohol exposure. AIM: To examine the effects of moderate levels of alcohol consumption during pregnancy on children's intellectual ability, learning and attention at 14 years of age. STUDY DESIGN AND SUBJECTS: The Mater-University of Queensland Study of Pregnancy involves a prospective birth cohort of 7223 singletons whose mothers were enrolled at the first antenatal visit. At 14 years, 5139 mothers and adolescents completed attentional and learning questionnaires, and 3731 adolescents completed psychometric assessments. OUTCOME MEASURES: For adolescents, the Wide Range Achievement Test--Revised (WRAT-R) and Raven's Standard Progressive Matrices Test (Raven's) were administered. Mothers completed the Child Behaviour Checklist (CBCL) and adolescents completed the Youth Self Report (YSR). Learning was assessed by a series of questions in the mother and adolescent questionnaires. Maternal measures included the quantity and frequency of alcohol consumption, and the extent of binge drinking. RESULTS: For consumption of <1 glass/day in early or late pregnancy, there was no association with any attention, learning or cognitive outcomes. The strongest estimates of effect were found among those consuming > or =1 glasses/day. Exposure in late pregnancy was associated with increased prevalence of overall learning difficulty in the unadjusted, although not the adjusted analysis. Binge drinking was associated with a higher prevalence of Raven's score <85 (1 standard deviation). CONCLUSIONS: Although a number of study limitations need to be considered, the results suggest that consumption at the level of <1 drink/day does not lead to adverse outcomes in relation to attention, learning and cognitive abilities, as measured in the current research. |
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Authors:
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Frances V O'Callaghan; Michael O'Callaghan; Jake M Najman; Gail M Williams; William Bor |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-07-12 |
Journal Detail:
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Title: Early human development Volume: 83 ISSN: 0378-3782 ISO Abbreviation: Early Hum. Dev. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-02-05 Completed Date: 2007-03-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7708381 Medline TA: Early Hum Dev Country: Ireland |
Other Details:
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Languages: eng Pagination: 115-23 Citation Subset: IM |
Affiliation:
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School of Psychology, Griffith University, Gold Coast, PMB 50 Gold Coast M.C., QLD 9726, Australia. f.ocallaghan@griffith.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adolescent Development / drug effects* Adult Alcohol Drinking* Attention / drug effects, physiology* Ethanol / adverse effects* Female Humans Intelligence / drug effects, physiology* Learning / drug effects, physiology* Longitudinal Studies Male Pregnancy Prenatal Exposure Delayed Effects* Prospective Studies Questionnaires Regression Analysis Socioeconomic Factors |
| Chemical | |
Reg. No./Substance:
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64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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