Document Detail


Prenatal programming of hypertension induces sympathetic overactivity in response to physical stress.
MedLine Citation:
PMID:  23150514     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Small-for-gestational-age infants are known to develop hypertension in adulthood. This prenatal programming of hypertension (PPH) can result from several insults including maternal dietary protein deprivation, uteroplacental insufficiency, and prenatal administration of glucocorticoids. The mechanisms underlying the development of hypertension remain unclear although the sympathetic nervous system has been indirectly implicated. This study was designed to directly measure renal sympathetic nerve activity both at rest and during physical stress in an animal model of PPH. The adult male offspring of rats fed either a 6% (PPH) or 20% protein diet (control) were investigated. Conscious systolic blood pressure measured by tail cuff was significantly higher in PPH compared with control (140 ± 3 versus 128 ± 3 mm Hg; P<0.05). Baseline mean arterial pressure, heart rate, and renal sympathetic activity were not different between groups during isoflurane anesthesia or after decerebration. Physical stress was induced in decerebrate animals by activating the exercise pressor reflex during static muscle contraction. Stimulation of the exercise pressor reflex evoked significantly larger changes from baseline in mean arterial pressure (40 ± 7 versus 20 ± 4 mm Hg; P<0.05), heart rate (19 ± 3 versus 5 ± 1 bpm; P<0.05), and renal sympathetic activity (198 ± 29% versus 68 ± 14%; P<0.05) in PPH as compared with control. The data demonstrate that the sympathetic response to physical stress is markedly exaggerated in PPH and may play a significant role in the development of hypertension in adults born small for gestational age.
Authors:
Masaki Mizuno; Khurrum Siddique; Michel Baum; Scott A Smith
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-11-12
Journal Detail:
Title:  Hypertension     Volume:  61     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-13     Completed Date:  2013-02-27     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  180-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / physiology*
Female
Fetal Development / physiology*
Heart Rate / physiology
Hypertension / embryology*,  physiopathology*
Kidney / innervation,  physiopathology
Male
Muscle Contraction / physiology
Muscle, Skeletal / innervation,  physiopathology
Pregnancy
Rats
Rats, Sprague-Dawley
Reflex / physiology
Stress, Physiological / physiology*
Sympathetic Nervous System / physiopathology*
Grant Support
ID/Acronym/Agency:
DK078596/DK/NIDDK NIH HHS; DK41612/DK/NIDDK NIH HHS; HL-088422/HL/NHLBI NIH HHS; P30DK 079328/DK/NIDDK NIH HHS; R01 HL088422/HL/NHLBI NIH HHS
Comments/Corrections
Comment In:
Hypertension. 2013 Jan;61(1):16-7   [PMID:  23150509 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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