| Prenatal Programming and Epigenetics in the Genesis of the Cardiorenal Syndrome. | |
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MedLine Citation:
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PMID: 22096456 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The presence of a group of interacting maladaptive factors, including hypertension, insulin resistance, metabolic dyslipidemia, obesity, and microalbuminuria and/or reduced renal function, collectively constitutes the cardiorenal metabolic syndrome (CRS). Nutritional and other environmental cues during fetal development can permanently affect the composition, homeostatic systems, and functions of multiple organs and systems; this process has been referred to as 'programming'. Since the original formulation of the notion that low birth weight is a proxy for 'prenatal programming' of adult hypertension and cardiovascular disease, evidence has also emerged for programming of kidney disease, insulin resistance, obesity, metabolic dyslipidemia, and other chronic diseases. The programming concept was initially predicated on the notion that in utero growth restriction due to famine was responsible for increased hypertension, and cardiovascular and renal diseases. On the other hand, we are now more commonly exposed to increasing rates of maternal obesity. The current review will discuss the overarching role of maternal overnutrition, as well as fetal undernutrition, in epigenetic programming in relation to the pathogenesis of the CRS in children and adults. |
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Authors:
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Ravi Nistala; Melvin R Hayden; Vincent G Demarco; Erik J Henriksen; Daniel T Lackland; James R Sowers |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-12 |
Journal Detail:
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Title: Cardiorenal medicine Volume: 1 ISSN: 1664-5502 ISO Abbreviation: - Publication Date: 2011 |
Date Detail:
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Created Date: 2011-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101554863 Medline TA: Cardiorenal Med Country: - |
Other Details:
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Languages: ENG Pagination: 243-254 Citation Subset: - |
Affiliation:
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University of Missouri Diabetes Cardiovascular Center, Columbia, Mo., USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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