| Prenatal and neonatal brain structure and white matter maturation in children at high risk for schizophrenia. | |
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MedLine Citation:
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PMID: 20516153 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Schizophrenia is a neurodevelopmental disorder associated with abnormalities of brain structure and white matter, although little is known about when these abnormalities arise. This study was conducted to identify structural brain abnormalities in the prenatal and neonatal periods associated with genetic risk for schizophrenia. METHOD: Prenatal ultrasound scans and neonatal structural magnetic resonance imaging (MRI) and diffusion tensor imaging were prospectively obtained in the offspring of mothers with schizophrenia or schizoaffective disorder (N=26) and matched comparison mothers without psychiatric illness (N=26). Comparisons were made for prenatal lateral ventricle width and head circumference, for neonatal intracranial, CSF, gray matter, white matter, and lateral ventricle volumes, and for neonatal diffusion properties of the genu and splenium of the corpus callosum and corticospinal tracts. RESULTS: Relative to the matched comparison subjects, the offspring of mothers with schizophrenia did not differ in prenatal lateral ventricle width or head circumference. Overall, the high-risk neonates had nonsignificantly larger intracranial, CSF, and lateral ventricle volumes. Subgroup analysis revealed that male high-risk infants had significantly larger intracranial, CSF, total gray matter, and lateral ventricle volumes; the female high-risk neonates were similar to the female comparison subjects. There were no group differences in white matter diffusion tensor properties. CONCLUSIONS: Male neonates at genetic risk for schizophrenia had several larger than normal brain volumes, while females did not. To the authors' knowledge, this study provides the first evidence, in the context of its limitations, that early neonatal brain development may be abnormal in males at genetic risk for schizophrenia. |
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Authors:
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John H Gilmore; Chaeryon Kang; Dianne D Evans; Honor M Wolfe; J Keith Smith; Jeffrey A Lieberman; Weili Lin; Robert M Hamer; Martin Styner; Guido Gerig |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-06-01 |
Journal Detail:
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Title: The American journal of psychiatry Volume: 167 ISSN: 1535-7228 ISO Abbreviation: Am J Psychiatry Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-09 Completed Date: 2010-09-24 Revised Date: 2013-04-08 |
Medline Journal Info:
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Nlm Unique ID: 0370512 Medline TA: Am J Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 1083-91 Citation Subset: AIM; IM |
Affiliation:
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Conte Schizophrenia Research Center and Department of Psychiatry, University of North Carolina at Chapel Hill, NC 27599-7160, USA. jgilmore@med.unc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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abnormalities*,
growth & development Brain Diseases / genetics*, pathology Female Humans Infant, Newborn Lateral Ventricles / abnormalities, pathology Magnetic Resonance Imaging / methods, statistics & numerical data Male Nervous System Malformations / genetics, pathology Pregnancy Prenatal Diagnosis / statistics & numerical data Psychotic Disorders / genetics, pathology Schizophrenia / genetics*, pathology |
| Grant Support | |
ID/Acronym/Agency:
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P50 MH-064065/MH/NIMH NIH HHS; P50 MH064065-06/MH/NIMH NIH HHS; U54 EB005149/EB/NIBIB NIH HHS |
| Comments/Corrections | |
Comment In:
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Am J Psychiatry. 2010 Sep;167(9):1017-9
[PMID:
20826850
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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