Document Detail


Prenatal and neonatal brain structure and white matter maturation in children at high risk for schizophrenia.
MedLine Citation:
PMID:  20516153     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Schizophrenia is a neurodevelopmental disorder associated with abnormalities of brain structure and white matter, although little is known about when these abnormalities arise. This study was conducted to identify structural brain abnormalities in the prenatal and neonatal periods associated with genetic risk for schizophrenia.
METHOD: Prenatal ultrasound scans and neonatal structural magnetic resonance imaging (MRI) and diffusion tensor imaging were prospectively obtained in the offspring of mothers with schizophrenia or schizoaffective disorder (N=26) and matched comparison mothers without psychiatric illness (N=26). Comparisons were made for prenatal lateral ventricle width and head circumference, for neonatal intracranial, CSF, gray matter, white matter, and lateral ventricle volumes, and for neonatal diffusion properties of the genu and splenium of the corpus callosum and corticospinal tracts.
RESULTS: Relative to the matched comparison subjects, the offspring of mothers with schizophrenia did not differ in prenatal lateral ventricle width or head circumference. Overall, the high-risk neonates had nonsignificantly larger intracranial, CSF, and lateral ventricle volumes. Subgroup analysis revealed that male high-risk infants had significantly larger intracranial, CSF, total gray matter, and lateral ventricle volumes; the female high-risk neonates were similar to the female comparison subjects. There were no group differences in white matter diffusion tensor properties.
CONCLUSIONS: Male neonates at genetic risk for schizophrenia had several larger than normal brain volumes, while females did not. To the authors' knowledge, this study provides the first evidence, in the context of its limitations, that early neonatal brain development may be abnormal in males at genetic risk for schizophrenia.
Authors:
John H Gilmore; Chaeryon Kang; Dianne D Evans; Honor M Wolfe; J Keith Smith; Jeffrey A Lieberman; Weili Lin; Robert M Hamer; Martin Styner; Guido Gerig
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-06-01
Journal Detail:
Title:  The American journal of psychiatry     Volume:  167     ISSN:  1535-7228     ISO Abbreviation:  Am J Psychiatry     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-09     Completed Date:  2010-09-24     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0370512     Medline TA:  Am J Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1083-91     Citation Subset:  AIM; IM    
Affiliation:
Conte Schizophrenia Research Center and Department of Psychiatry, University of North Carolina at Chapel Hill, NC 27599-7160, USA. jgilmore@med.unc.edu
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MeSH Terms
Descriptor/Qualifier:
Brain / abnormalities*,  growth & development
Brain Diseases / genetics*,  pathology
Female
Humans
Infant, Newborn
Lateral Ventricles / abnormalities,  pathology
Magnetic Resonance Imaging / methods,  statistics & numerical data
Male
Nervous System Malformations / genetics,  pathology
Pregnancy
Prenatal Diagnosis / statistics & numerical data
Psychotic Disorders / genetics,  pathology
Schizophrenia / genetics*,  pathology
Grant Support
ID/Acronym/Agency:
P50 MH-064065/MH/NIMH NIH HHS; P50 MH064065-06/MH/NIMH NIH HHS; U54 EB005149/EB/NIBIB NIH HHS
Comments/Corrections
Comment In:
Am J Psychiatry. 2010 Sep;167(9):1017-9   [PMID:  20826850 ]

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