Document Detail

Prenatal MgSO4 treatment modifies the erythrocyte band 3 in preterm neonates.
MedLine Citation:
PMID:  16481194     Owner:  NLM     Status:  MEDLINE    
Magnesium sulphate that is widely used to prevent preterm labour or treatment for imminent eclampsia is also suggested to decrease a cerebral palsy in preterm newborns. However, the molecular mechanism of MgSO4 protection in fetus remains unknown. Since Mg2+ very rapidly crosses the placenta, we assayed whether it may exert an effect on newborn erythrocytes, particularly on anion exchange band 3. The study groups consisted of preterm neonates born from mothers who received prenatally magnesium sulphate and a control group, without prenatal Mg2+ administration. We compared the selected erythrocyte parameters including ATP concentration, membrane lipids peroxidation, the band 3 amount and its phosphotyrosine level, assayed after delivery and 24h later. At birth, ATP concentration was higher in control newborns and decreased after 24h, reaching the level found in the MgSO4-treated group. Band 3 and P-Tyr amounts were unchanged in MgSO4-treated newborns during examined period. In the control group, the lower Mg concentration after delivery correlated with the lowered band 3 phosphorylation. We have also observed enlarged TBARS content in control membranes. Our results demonstrate that prenatal administration of magnesium sulphate significantly altered some erythrocyte parameters. These data suggest that MgSO4 may modify the erythrocytes metabolism in preterm newborns. Since band 3 exhibits the same structural and functional activities as in the brain, the elucidation of MgSO4 influence is of special importance.
Ewa Gulczynska; Janusz Gadzinowski; Jan Wilczynski; Ludmila Zylinska
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-02-14
Journal Detail:
Title:  Pharmacological research : the official journal of the Italian Pharmacological Society     Volume:  53     ISSN:  1043-6618     ISO Abbreviation:  Pharmacol. Res.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-17     Completed Date:  2006-06-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8907422     Medline TA:  Pharmacol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  347-52     Citation Subset:  IM    
Department of Neonatology, Research Institute of Polish Mother's Memorial Hospital, 281/289 Rzgowska Street, 93-338 Lodz, Poland.
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MeSH Terms
Adenosine Triphosphate / blood
Anion Exchange Protein 1, Erythrocyte / metabolism*
Erythrocyte Membrane / drug effects,  metabolism
Erythrocytes / drug effects*,  metabolism*
Fetal Blood
Infant, Newborn / blood*
Lipid Peroxidation / drug effects
Magnesium / blood
Magnesium Sulfate / pharmacology*
Membrane Lipids / blood
Phosphorylation / drug effects
Prenatal Exposure Delayed Effects
Reg. No./Substance:
0/Anion Exchange Protein 1, Erythrocyte; 0/Membrane Lipids; 56-65-5/Adenosine Triphosphate; 7439-95-4/Magnesium; 7487-88-9/Magnesium Sulfate

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