Document Detail

Prenatal Genotyping of the RhD Locus to Identify Fetuses at Risk for Hemolytic Disease of the Newborn.
MedLine Citation:
PMID:  21370158     Owner:  NLM     Status:  In-Data-Review    
Hemolytic disease of the newborn (HDN) can occur when there are fetomaternal incompatibilities within any number of different erythrocyte antigen systems, including the RhD, Cc, Ee, Kidd and Duffy, and Kell antigen systems. In these disorders, maternal antibodies are developed by alloimmunization of the mother to fetal red blood cells during pregnancy when the fetal cells carry an alloantigen inherited from the father. The maternal antibodies result in the destruction of fetal erythrocytes leading to severe hemolytic anemia and hyperbilirubinemia. Permanent neurologic damage can result from HDN, and in extreme cases loss of the fetus or death of the neonate may occur. In subsequent pregnancies, it is important to determine the status of the incompatible allele in the fetus. If the father is heterozygous or homozygous for the allele, the chance of the fetus inheriting the paternal alloallele to which the mother is immunologically sensitized is 50 or 100%, respectively. Fetuses that do not inherit the alloallele will not be at risk for HDN.
M J Hessner; D B Bellissimo
Related Documents :
21252808 - Pregnancy in inherited hypokalemic salt-losing renal tubular disorder.
318408 - Vitellogenin, lipid and carbohydrate metabolism during vitellogenesis and pregnancy, an...
21542428 - Fetal acoustic stimulation test for early intrapartum fetal monitoring.
21264878 - Hematological effects of zidovudine prophylaxis in newborn infants with and without pre...
16728178 - The relationship of rheological behavior of the vaginal fluid at the time of inseminati...
14504868 - Fetal grasping of the umbilical cord and perinatal outcome.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in molecular medicine     Volume:  49     ISSN:  1543-1894     ISO Abbreviation:  Methods Mol. Med.     Publication Date:  2001  
Date Detail:
Created Date:  2011-03-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101123138     Medline TA:  Methods Mol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  427-37     Citation Subset:  -    
Diagnostic Laboratories, The Blood Center of Southeastern Wisconsin, Milwaukee, WI.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Molecular diagnosis of hereditary thrombotic disorders.
Next Document:  Molecular diagnosis of hereditary hemochromatosis.