| Prenatal exposure to apoE deficiency and postnatal hypercholesterolemia are associated with altered cell-specific lysine methyltransferase and histone methylation patterns in the vasculature. | |
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MedLine Citation:
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PMID: 20035052 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We recently demonstrated that neointima formation of adult heterozygous apolipoprotein E (apoE(+/-)) offspring from hypercholesterolemic apoE(-/-) mothers was significantly increased as compared with genetically identical apoE(+/-) offspring from normocholesterolemic wild-type mothers. Since atherosclerosis is the consequence of a complex microenvironment and local cellular interactions, the effects of in utero programming and type of postnatal diet on epigenetic histone modifications in the vasculature were studied in both groups of offspring. An immunohistochemical approach was used to detect cell-specific histone methylation modifications and expression of accompanying lysine methyltransferases in the carotid arteries. Differences in histone triple-methylation modifications in vascular endothelial and smooth muscle cells revealed that the offspring from apoE(-/-) mothers had significantly different responses to a high cholesterol diet when compared with offspring from wild-type mothers. Our results suggest that both in utero programming and postnatal hypercholesterolemia affect epigenetic patterning in the vasculature, thereby providing novel insights regarding initiation and progression of vascular disease in adults. |
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Authors:
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Fanneke E Alkemade; Patrick van Vliet; Peter Henneman; Ko Willems van Dijk; Beerend P Hierck; J Conny van Munsteren; Joyce A Scheerman; Jelle J Goeman; Louis M Havekes; Adriana C Gittenberger-de Groot; Peter J van den Elsen; Marco C DeRuiter |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-24 |
Journal Detail:
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Title: The American journal of pathology Volume: 176 ISSN: 1525-2191 ISO Abbreviation: Am. J. Pathol. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-26 Completed Date: 2010-03-16 Revised Date: 2011-07-22 |
Medline Journal Info:
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Nlm Unique ID: 0370502 Medline TA: Am J Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 542-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Anatomy and Embryology, Leiden University Medical Center, PO BOX 9600, 2300 RC Leiden, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Apolipoproteins E / deficiency, genetics* Blood Vessels / metabolism* Diet Epigenesis, Genetic / physiology Female Histone-Lysine N-Methyltransferase / metabolism* Histones / metabolism Hypercholesterolemia / enzymology, genetics, metabolism* Lysine / metabolism Maternal Nutritional Physiological Phenomena Methylation Methyltransferases / metabolism* Mice Mice, Inbred C57BL Mice, Transgenic Organ Specificity Pregnancy Prenatal Exposure Delayed Effects / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E; 0/Histones; 56-87-1/Lysine; EC 2.1.1.-/Methyltransferases; EC 2.1.1.-/histone methyltransferase; EC 2.1.1.43/Histone-Lysine N-Methyltransferase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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