| Prenatal Exposure to Organochlorine Compounds and Birth Size. | |
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MedLine Citation:
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PMID: 21669889 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: To investigate the possible association between birth size and cord concentrations of some organochlorine compounds (OCs), including 4,4'-dichlorodiphenyltrichloroethane (DDT), 4,4'-1,1-dichloro-2,2-bis(p-dichlorodiphenyl)ethylene (DDE), hexachlorobenzene (HCB), β-hexachlorocyclohexane (β-HCH), 4 polychlorinated biphenyl (PCB) congeners (118, 138, 153, and 180), and their sum (ΣPCBs) in a birth cohort in Valencia, Spain. Study Design: A total of 494 mothers and their newborns (born 2003-2006) participated in the study. Multivariate linear regression analyses were performed between birth weight, length, or head circumference and OC concentrations. Results: Median concentrations of 4,4'-DDT, 4,4'-DDE, HCB, β-HCH, and ΣPCBs were 0.02, 0.46, 0.22, 0.09, and 0.35 ng/mL, respectively. For birth weight there was a significant decrease of 63 and 107 g for each 10-fold increase in cord serum 4,4'-DDT and 4,4'-DDE concentrations, and a marginally significant decrease of 79 and 53 g for each 10-fold increase in HCB and β-HCH concentrations. A significant decrease of 0.39 cm in birth length was found for each 10-fold increase in HCB concentrations. For newborns with cord 4,4'-DDT concentrations above the median there was a significant decrease of 0.26 cm in birth head circumference. Conclusions: These results reveal that prenatal exposure to some OCs could impair the anthropometric development of the fetus, reducing the birth weight, length, and head circumference. |
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Authors:
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Maria-Jose Lopez-Espinosa; Mario Murcia; Carmen Iñiguez; Esther Vizcaino; Sabrina Llop; Jesus Vioque; Joan O Grimalt; Marisa Rebagliato; Ferran Ballester |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-13 |
Journal Detail:
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Title: Pediatrics Volume: - ISSN: 1098-4275 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Centre for Public Health Research, Conselleria de Sanitat, Valencia, Spain; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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