| Prenatal exposure to mercury and infant neurodevelopment in a multicenter cohort in Spain: study of potential modifiers. | |
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MedLine Citation:
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PMID: 22287639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vulnerability of the central nervous system to mercury is increased during early development. This study aimed to evaluate whether cord blood total mercury levels may have a negative effect on both mental and psychomotor development in a maternal-birth cohort from moderate-high fish consumption areas. Study subjects were 1,683 child participants in the INMA (Environment and Childhood) Project from 4 areas of Spain between 2003 and 2010. Cord blood total mercury levels were analyzed by atomic absorption spectrometry. Infant neurodevelopment was assessed around age 14 months by the Bayley Scales of Infant Development. Sociodemographic, lifestyle, and dietary information was obtained by questionnaire during pregnancy. The geometric mean of total mercury levels was 8.4 μg/L (95% confidence interval (CI): 8.1, 8.7). In multivariate analysis, a doubling in total mercury levels did not show an association with mental (β = 0.1, 95% CI: -0.68, 0.88) or psychomotor (β = -0.05, 95% CI: -0.79, 0.68) developmental delay; however, stratified findings by sex suggest a negative association between prenatal exposure to total mercury and psychomotor development among female infants (β = -1.09, 95% CI: -2.21, 0.03), although follow-up is required to confirm these results. |
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Authors:
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Sabrina Llop; Mònica Guxens; Mario Murcia; Aitana Lertxundi; Rosa Ramon; Isolina Riaño; Marisa Rebagliato; Jesus Ibarluzea; Adonina Tardon; Jordi Sunyer; Ferran Ballester; |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2012-01-27 |
Journal Detail:
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Title: American journal of epidemiology Volume: 175 ISSN: 1476-6256 ISO Abbreviation: Am. J. Epidemiol. Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-21 Completed Date: 2012-05-22 Revised Date: 2013-01-29 |
Medline Journal Info:
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Nlm Unique ID: 7910653 Medline TA: Am J Epidemiol Country: United States |
Other Details:
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Languages: eng Pagination: 451-65 Citation Subset: IM |
Affiliation:
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Centre for Public Health Research, Valencia, Spain. llop_sab@gva.es |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cohort Studies Developmental Disabilities / blood, chemically induced* Diet Surveys Effect Modifier, Epidemiologic Female Fetal Blood / chemistry* Food Contamination Humans Infant Linear Models Male Mercury / blood, toxicity* Multivariate Analysis Pregnancy Prenatal Exposure Delayed Effects / blood, chemically induced* Psychological Tests Psychomotor Disorders / blood, chemically induced* Psychomotor Performance / drug effects Seafood Sex Factors Spain Water Pollutants, Chemical / blood, toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Water Pollutants, Chemical; 7439-97-6/Mercury |
| Comments/Corrections | |
Comment In:
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Am J Epidemiol. 2012 Dec 15;176(12):1194-5; author reply 1195-6
[PMID:
23161896
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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