Document Detail


Prenatal exposure to mercury and fish consumption during pregnancy and attention-deficit/hyperactivity disorder-related behavior in children.
MedLine Citation:
PMID:  23044994     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the association of prenatal mercury exposure and fish intake with attention-deficit/hyperactivity disorder (ADHD)-related behavior.
METHODS: For a population-based prospective birth cohort recruited in New Bedford, Massachusetts (1993-1998), we analyzed data for children examined at age 8 years with peripartum maternal hair mercury measures (n = 421) or maternal report of fish consumption during pregnancy (n = 515). Inattentive and impulsive/hyperactive behaviors were assessed using a teacher rating scale and neuropsychological testing.
RESULTS: The median maternal hair mercury level was 0.45 μg/g (range, 0.03-5.14 μg/g), and 52% of mothers consumed more than 2 fish servings weekly. In multivariable regression models, mercury exposure was associated with inattention and impulsivity/hyperactivity; some outcomes had an apparent threshold with associations at 1 μg/g or greater of mercury. For example, at 1 μg/g or greater, the adjusted risk ratios for mild/markedly atypical inattentive and impulsive/hyperactive behaviors were 1.4 (95% CI, 1.0-1.8) and 1.7 (95% CI, 1.2-2.4), respectively, for an interquartile range (0.5 μg/g) mercury increase; there was no confounding by fish consumption. For neuropsychological assessments, mercury and behavior associations were detected primarily for boys. There was a protective association for fish consumption (>2 servings per week) with ADHD-related behaviors, particularly impulsive/hyperactive behaviors (relative risk = 0.4; 95% CI, 0.2-0.6).
CONCLUSIONS: Low-level prenatal mercury exposure is associated with a greater risk of ADHD-related behaviors, and fish consumption during pregnancy is protective of these behaviors. These findings underscore the difficulties of balancing the benefits of fish intake with the detriments of low-level mercury exposure in developing dietary recommendations in pregnancy.
Authors:
Sharon K Sagiv; Sally W Thurston; David C Bellinger; Chitra Amarasiriwardena; Susan A Korrick
Related Documents :
20668464 - Clinical and biochemical improvement of very long-chain acyl-coa dehydrogenase deficien...
3374914 - Bulimia nervosa in pregnancy: a case report.
18308554 - Lithium toxicity and the parturient: case report and literature review.
18564524 - Diabetes in pregnancy--dietary management.
11355794 - Endocrinopathies associated with recurrent pregnancy loss.
17259714 - Clinical outcomes of tubal heterotopic pregnancy: assisted vs. spontaneous conceptions.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Archives of pediatrics & adolescent medicine     Volume:  166     ISSN:  1538-3628     ISO Abbreviation:  Arch Pediatr Adolesc Med     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2013-02-01     Completed Date:  2013-03-11     Revised Date:  2014-04-22    
Medline Journal Info:
Nlm Unique ID:  9422751     Medline TA:  Arch Pediatr Adolesc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1123-31     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Attention Deficit Disorder with Hyperactivity / chemically induced*,  diagnosis,  prevention & control
Child
Diet* / adverse effects
Diet Surveys
Female
Food Contamination
Hair / chemistry
Humans
Linear Models
Male
Massachusetts
Maternal Exposure / adverse effects*,  statistics & numerical data
Mercury / analysis,  toxicity*
Multivariate Analysis
Pregnancy
Prenatal Exposure Delayed Effects / chemically induced*,  diagnosis,  prevention & control
Prenatal Nutritional Physiological Phenomena
Prospective Studies
Psychological Tests
Questionnaires
Seafood* / adverse effects
Water Pollutants, Chemical / analysis,  toxicity*
Young Adult
Grant Support
ID/Acronym/Agency:
P42 ES005947/ES/NIEHS NIH HHS; P42 ES016454/ES/NIEHS NIH HHS; P42 ES016454/ES/NIEHS NIH HHS; P42 ES05947/ES/NIEHS NIH HHS; R01 ES014864/ES/NIEHS NIH HHS; R01 ES014864/ES/NIEHS NIH HHS; R03 ES016604/ES/NIEHS NIH HHS; R03 ES016604/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Water Pollutants, Chemical; FXS1BY2PGL/Mercury
Comments/Corrections
Comment In:
Arch Pediatr Adolesc Med. 2012 Dec;166(12):1182-4   [PMID:  23045166 ]
Summary for patients in:
Arch Pediatr Adolesc Med. 2012 Dec;166(12):1188   [PMID:  23208646 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Deletion of CD74, a putative MIF receptor, in mice enhances osteoclastogenesis and decreases bone ma...
Next Document:  T? mapping provides multiple approaches for the characterization of muscle involvement in neuromuscu...