Document Detail


Prenatal alcohol exposure alters biobehavioral reactivity to pain in newborns.
MedLine Citation:
PMID:  20121718     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To examine biobehavioral responses to an acute pain event in a Cape Town, South Africa, cohort consisting of 28 Cape Colored (mixed ancestry) newborns (n = 14) heavily exposed to alcohol during pregnancy (exposed), and born to abstainers (n = 14) or light (< or = 0.5 oz absolute alcohol/d) drinkers (controls).
METHODS: Mothers were recruited during the third trimester of pregnancy. Newborn data were collected on postpartum day 3 in the maternity obstetrical unit where the infant had been delivered. Heavy prenatal alcohol exposure was defined as maternal consumption of at least 14 drinks/wk or at least 1 incident of binge drinking/mo. Acute stress-related biobehavioral markers [salivary cortisol, heart rate (HR), respiratory sinus arrhythmia (RSA), spectral measures of heart rate variability (HRV), and videotaped facial actions] were collected thrice during a heel lance blood collection (baseline, lance, and recovery). After a feeding and nap, newborns were administered an abbreviated Brazelton Neonatal Behavioral Assessment Scale.
RESULTS: There were no between-group differences in maternal age, marital status, parity, gravidity, depression, anxiety, pregnancy smoking, maternal education, or infant gestational age at birth (all ps > 0.15). In both groups, HR increased with the heel lance and decreased during the postlance period. The alcohol-exposed group had lower mean HR than controls throughout, and showed no change in RSA over time. Cortisol levels showed no change over time in controls but decreased over time in exposed infants. Although facial action analyses revealed no group differences in response to the heel lance, behavioral responses assessed on the Brazelton Neonatal Scale showed less arousal in the exposed group.
CONCLUSIONS: Both cardiac autonomic and hypothalamic-pituitary-adrenal stress reactivity measures suggest a blunted response to an acute noxious event in alcohol-exposed newborns. This is supported by results on the Brazelton Neonatal Scale indicating reduced behavioral arousal in the exposed group. To our knowledge, these data provide the first biobehavioral examination of early pain reactivity in alcohol-exposed newborns and have important implications for understanding neuro-/biobehavioral effects of prenatal alcohol exposure in the newborn period.
Authors:
Tim F Oberlander; Sandra W Jacobson; Joanne Weinberg; Ruth E Grunau; Christopher D Molteno; Joseph L Jacobson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-27
Journal Detail:
Title:  Alcoholism, clinical and experimental research     Volume:  34     ISSN:  1530-0277     ISO Abbreviation:  Alcohol. Clin. Exp. Res.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-21     Completed Date:  2010-11-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7707242     Medline TA:  Alcohol Clin Exp Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  681-92     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada. toberlander@cw.bc.ca
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcohol Drinking / adverse effects*,  psychology
Cohort Studies
Female
Fetal Alcohol Syndrome / diagnosis,  etiology,  psychology*
Humans
Infant Behavior / physiology,  psychology*
Infant, Newborn
Male
Pain / diagnosis,  psychology*
Pain Measurement / methods,  psychology*
Pregnancy
Prenatal Exposure Delayed Effects / diagnosis,  etiology,  psychology*
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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