Document Detail

Premorbid proneness to distress and episodic memory impairment in Alzheimer's disease.
MedLine Citation:
PMID:  14742585     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Chronic stress has been associated with impaired episodic memory, but the association of premorbidly experienced distress with memory function in Alzheimer's disease is unknown. OBJECTIVE: To investigate the link between proneness to distress and Alzheimer's disease. METHODS: Participants were 363 persons with clinically diagnosed Alzheimer's disease. At baseline, a knowledgeable informant rated each person's premorbid personality (that is, before dementia onset) along five dimensions, one of which was the tendency to experience psychological distress. Participants underwent structured clinical evaluations at baseline and then annually for up to four years. Each evaluation included 17 cognitive tests from which previously established measures of episodic memory, visuoconstruction, repetition, and naming were derived. RESULTS: In a series of random effects models adjusted for age, sex, and education, premorbid distress proneness was associated with baseline impairment in episodic memory but not with impairment in other cognitive domains, or with change in any cognitive domain. No other trait was related to baseline function or rate of decline in any cognitive domain. CONCLUSIONS: The results suggest that premorbid proneness to experience psychological distress is related to level of impairment in episodic memory in persons with Alzheimer's disease, but neither distress proneness nor other personality traits are related to disease progression.
R S Wilson; D A Fleischman; R A Myers; D A Bennett; J L Bienias; D W Gilley; D A Evans
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  75     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-01-26     Completed Date:  2004-03-11     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  191-5     Citation Subset:  IM    
Rush Alzheimer's Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA.
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MeSH Terms
Alzheimer Disease / psychology*
Cognition Disorders / diagnosis,  epidemiology
Depressive Disorder, Major / diagnosis,  epidemiology,  etiology*
Follow-Up Studies
Memory Disorders / diagnosis*,  epidemiology
Neuropsychological Tests
Personality Disorders / diagnosis,  epidemiology
Severity of Illness Index
Time Factors
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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