Document Detail

Premorbid body mass index and risk of amyotrophic lateral sclerosis.
MedLine Citation:
PMID:  23134505     Owner:  NLM     Status:  MEDLINE    
Our objective was to determine if amyotrophic lateral sclerosis (ALS) risk varies according to body mass index (BMI) captured up to three decades earlier. At baseline 537,968 females and 562,942 males in five ongoing cohorts reported height, current weight and weight at age 18/21 years. During 14-28 years of follow-up, 1153 participants developed ALS. Cohort-specific Cox proportional hazards models were used to estimate rates that were then pooled with random-effects models. Results showed that lower BMI at baseline was associated with ALS; for each 5-unit increase in BMI, ALS rates were 21% lower (95% CI 14% 27%). Compared to individuals with healthy BMI, ALS rates were significantly lower among the overweight (RR = 0.76 (95% CI 0.62-0.93)) and obese (RR = 0.73 (95% CI 0.55-0.96)). Among never smokers the association persisted: RR = 0.75 (95% CI 0.65-0.85) for each 5-unit increase. Excluding the first seven years of follow-up, the associations were materially unchanged suggesting that weight loss from undiagnosed disease does not fully explain the findings. Overall, 75% of males and females had a healthy BMI at age 18/21 years, 15% of males and 8% of females were overweight or obese; there was no association with ALS although numbers with an unhealthy weight were small. In conclusion, these findings support an association between lower premorbid BMI and ALS.
Éilis J O'Reilly; Hao Wang; Marc G Weisskopf; Kathryn C Fitzgerald; Guido Falcone; Marjorie L McCullough; Michael Thun; Yikyung Park; Laurence N Kolonel; Alberto Ascherio
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-10-29
Journal Detail:
Title:  Amyotrophic lateral sclerosis & frontotemporal degeneration     Volume:  14     ISSN:  2167-9223     ISO Abbreviation:  Amyotroph Lateral Scler Frontotemporal Degener     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-29     Completed Date:  2013-12-27     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  101587185     Medline TA:  Amyotroph Lateral Scler Frontotemporal Degener     Country:  England    
Other Details:
Languages:  eng     Pagination:  205-11     Citation Subset:  IM    
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MeSH Terms
Amyotrophic Lateral Sclerosis / diagnosis*,  epidemiology*,  physiopathology
Body Mass Index*
Cohort Studies
Follow-Up Studies
Longitudinal Studies
Middle Aged
Obesity / diagnosis*,  epidemiology*,  physiopathology
Prospective Studies
Risk Factors
Young Adult
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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